[3β(S),5β,12α]-[[1,4-bis(carboxymethyl)-6-[bis(carboxymethyl)]amino-1,4-diazepan-6-ylmethyl]-3-amino]-12-hydroxycholan-24-oic acid | 1174734-05-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: [3β(S),5β,12α]-[[1,4-bis(carboxymethyl)-6-[bis(carboxymethyl)]amino-1,4-diazepan-6-ylmethyl]-3-amino]-12-hydroxycholan-24-oic acid
• CAS: 1174734-05-4
• 化学式: C₃₈H₆₂N₄O₁₁
• 分子量: 750.93
• InChiKey: MQMJHQAZAULYBI-LUIGJBOBSA-N

反应信息

• 作为产物：
  描述：

  在 三氟乙酸 、 sodium hydroxide 作用下， 以 二氯甲烷 、 水 为溶剂， 反应 17.0h， 以42 mg的产率得到[3β(S),5β,12α]-[[1,4-bis(carboxymethyl)-6-[bis(carboxymethyl)]amino-1,4-diazepan-6-ylmethyl]-3-amino]-12-hydroxycholan-24-oic acid
  参考文献：
  名称：

  Fast and easy access to efficient bifunctional chelators for MRI applications

  摘要：

  Novel bifunctional agents based on the AAZTA (6-amino-6-methylperhydro-1,4-diazepinetetraacetic acid) structure with hydroxyl, carboxyl and chloro functional groups were prepared. The Gd-III complexes show optimal magnetic properties making them very good candidates for conjugation to biomolecules for molecular imaging applications. An example of conjugation to a bile acid derivative is also reported. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.05.024