2-(4-phenylpiperazin-1-ylmethyl)indole-3-carbaldehyde oxime | 459448-42-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 2-(4-phenylpiperazin-1-ylmethyl)indole-3-carbaldehyde oxime
• CAS: 459448-42-1
• 化学式: C₂₀H₂₂N₄O
• 分子量: 334.421
• InChiKey: CVCVTMULKVMAMX-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  2-(4-phenylpiperazin-1-ylmethyl)indole-3-carbaldehyde oxime 在 三乙胺 、 三氟乙酸酐 作用下， 以 四氢呋喃 为溶剂， 反应 4.0h， 以67%的产率得到2-(4-Phenylpiperazin-1-ylmethyl)-1H-indole-3-carbonitrile
  参考文献：
  名称：

  Phenylpiperazinylmethylindolecarboxylates and derivatives as selective D4-Ligands

  摘要：

  Novel phenylpiperazinylmethylindolecarboxylates were synthesized for evaluation as potential D-4-ligands. Test compounds showed high affinity for the human dopamine D-4 receptor and great selectivity over the other receptor subtypes. Intrinsic effects of indole derivatives, which indicated most promising binding properties, were investigated in a mitogenesis assay. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(02)00042-1
• 作为产物：
  描述：

  2-(4-Phenylpiperazin-1-ylmethyl)-1H-indole-3-carbaldehyde 在 盐酸羟胺 、 三乙胺 作用下， 以 乙醇 为溶剂， 反应 3.0h， 以63%的产率得到2-(4-phenylpiperazin-1-ylmethyl)indole-3-carbaldehyde oxime
  参考文献：
  名称：

  Phenylpiperazinylmethylindolecarboxylates and derivatives as selective D4-Ligands

  摘要：

  Novel phenylpiperazinylmethylindolecarboxylates were synthesized for evaluation as potential D-4-ligands. Test compounds showed high affinity for the human dopamine D-4 receptor and great selectivity over the other receptor subtypes. Intrinsic effects of indole derivatives, which indicated most promising binding properties, were investigated in a mitogenesis assay. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(02)00042-1