4,5,5-Triphenyl-tetrahydro-furan-2-ol | 211819-59-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 4,5,5-Triphenyl-tetrahydro-furan-2-ol
• CAS: 211819-59-9
• 化学式: C₂₂H₂₀O₂
• 分子量: 316.4
• InChiKey: AWEXOJGFVXYROH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.45
• 重原子数：
  24.0
• 可旋转键数：
  3.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  29.46
• 氢给体数：
  1.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  4,5,5-Triphenyl-tetrahydro-furan-2-ol 在 silver carbonate 作用下， 以 甲苯 为溶剂， 以67%的产率得到4,5,5-triphenyldihydrofuran-2(3H)-one
  参考文献：
  名称：

  Diastereoselective Synthesis of Highly Substituted Five-Membered-Ring Oxygen Heterocycles by Zirconocene-Mediated C-C Coupling Reactions

  摘要：

  As homoenolate equivalents, zirconocene-1-aza-1,3-diene complexes were used for the first time in stereoselective synthesis. By insertion of an unsymmetrical ketone in the Zr-C σ bond, sterically demanding trisubstituted dihydro- and tetrahydrofuran derivatives were prepared in good overall yields and with high diastereoselectivities (see below).

  DOI：

  10.1002/(sici)1521-3773(19980703)37:12<1673::aid-anie1673>3.0.co;2-a
• 作为产物：
  描述：

  在 盐酸 、 水 作用下， 以 四氢呋喃 为溶剂， 反应 6.0h， 生成 4,5,5-Triphenyl-tetrahydro-furan-2-ol
  参考文献：
  名称：

  Diastereoselective Synthesis of Highly Substituted Five-Membered-Ring Oxygen Heterocycles by Zirconocene-Mediated C-C Coupling Reactions

  摘要：

  As homoenolate equivalents, zirconocene-1-aza-1,3-diene complexes were used for the first time in stereoselective synthesis. By insertion of an unsymmetrical ketone in the Zr-C σ bond, sterically demanding trisubstituted dihydro- and tetrahydrofuran derivatives were prepared in good overall yields and with high diastereoselectivities (see below).

  DOI：

  10.1002/(sici)1521-3773(19980703)37:12<1673::aid-anie1673>3.0.co;2-a