N-(4-Methylamino-cyclohexyl)-acetamide | 1154623-10-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-(4-Methylamino-cyclohexyl)-acetamide
• 英文别名: N-[4-(methylamino)cyclohexyl]acetamide
• CAS: 1154623-10-5
• 化学式: C₉H₁₈N₂O
• 分子量: 170.25
• InChiKey: LWVNJCHQJBWIKU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  41.1
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• Benzene, Pyridine, and Pyridazine Derivatives
  申请人：Huang Kenneth He

  公开号：US20080119457A1

  公开（公告）日：2008-05-22

  Disclosed are compounds and pharmaceutically acceptable salts of Formula I wherein A, Q 1 , Q 2 , Q 3 , R 31 , and R 41 are as defined herein. Compounds of Formula I are useful in the treatment of diseases and/or conditions related to cell proliferation, such as cancer, inflammation, arthritis, angiogenesis, or the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.

  公开了公式I的化合物和药用盐，其中A、Q1、Q2、Q3、R31和R41如本文所定义。公式I的化合物在治疗与细胞增殖相关的疾病和/或病况方面具有用途，如癌症、炎症、关节炎、血管生成等。还公开了包括本发明化合物的药物组合物以及使用这些化合物治疗上述病况的方法。
• TWO-PHOTON ABSORBING FLUOROPHORES AND METHOD FOR CELLULAR IMAGING USING THE SAME
  申请人：POSTECH ACADEMY-INDUSTRY FOUNDATION

  公开号：US20170327509A1

  公开（公告）日：2017-11-16

  The present invention relates to new one-photon or two-photon absorbing fluorophores, a method for preparing the same, and a method for cellular imaging using the same, and more particularly, to new two-photon absorbing fluorophores having higher fluorescence quantum yield and two-photon absorption cross-section value than those of the conventional two-photon absorbing fluorophore, acedan, and thus are promisingly applicable in bioimaging. The design strategy and the compounds according to the present invention may practically utilized for developing new D-π-A fluorophores.

  本发明涉及新的单光子或双光子吸收荧光团，以及制备该荧光团的方法和利用该荧光团进行细胞成像的方法，更特别地，涉及具有比传统的双光子吸收荧光团acedan的荧光量子产率和双光子吸收截面值更高的新的双光子吸收荧光团，因此在生物成像中有着广泛的应用前景。根据本发明的设计策略和化合物可实际用于开发新的D-π-A荧光团。
• Pyrimidine and Pyrazine Derivatives
  申请人：Huang He Kenneth

  公开号：US20080070930A1

  公开（公告）日：2008-03-20

  Disclosed are compounds and pharmaceutically acceptable salts of Formula I wherein R 0 , R 3 , R 7 , n, Q 1 , Q 2 , Y, and X 1 -X 3 are as defined herein. Compounds of Formula I are useful in the treatment of diseases and/or conditions related to cell proliferation, such as cancer, inflammation, arthritis, angiogenesis, or the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.

  本发明揭示了I式化合物及其药学上可接受的盐，其中R0、R3、R7、n、Q1、Q2、Y和X1-X3如本文所定义。I式化合物在治疗与细胞增殖有关的疾病和/或病况（如癌症、炎症、关节炎、血管生成等）方面具有用途。本发明还揭示了包括本发明化合物的药物组合物和使用这些化合物治疗上述病况的方法。
• Dihydropyridazine, Tetrahydropyridine, Chromanone, and Dihydronaphthalenone Derivatives
  申请人：Huang He Kenneth

  公开号：US20080070918A1

  公开（公告）日：2008-03-20

  Disclosed are compounds and pharmaceutically acceptable salts of Formula I wherein A, Q 1 , Q 2 , Q 3 , R 3 , and R 4 are as defined herein. Compounds of Formula I are useful in the treatment of diseases and/or conditions related to cell proliferation, such as cancer, inflammation, arthritis, angiogenesis, or the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.

  本发明涉及公式I的化合物和药学上可接受的盐，其中A、Q1、Q2、Q3、R3和R4的定义如本文所述。公式I的化合物在治疗与细胞增殖有关的疾病和/或情况，如癌症、炎症、关节炎、血管生成等方面具有用途。本发明还涉及包含本发明化合物的制药组合物以及使用这些化合物治疗上述疾病和情况的方法。
• COMPOUNDS FOR TREATING NEUROPSYCHIATRIC CONDITIONS
  申请人：Campbell David

  公开号：US20120046283A1

  公开（公告）日：2012-02-23

  Provided herein are PAK inhibitors and methods of utilizing PAK inhibitors for the treatment of neuropsychiatric conditions.

  本文提供了PAK抑制剂及其在治疗神经精神疾病方面的应用方法。