(4-Isopropyl-1H-imidazol-2-YL)methanamine | 944898-09-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (4-Isopropyl-1H-imidazol-2-YL)methanamine
• 英文别名: (5-propan-2-yl-1H-imidazol-2-yl)methanamine
• CAS: 944898-09-3
• 化学式: C₇H₁₃N₃
• 分子量: 139.2
• InChiKey: QEGOOMXWHGVBJN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  54.7
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• Triaryl compounds for treatment of PD-L1 diseases
  申请人：CHEMOCENTRYX, INC.

  公开号：US11266643B2

  公开（公告）日：2022-03-08

  Compounds are provided that are useful as immunomodulators. The compounds have the Formula (I) including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1a, R1b, R1c, R1d, R2a, R2b, R3, R3a, R4, R6, R7, R8, A, Z, X1 and n are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

  本研究提供了可用作免疫调节剂的化合物。这些化合物具有式（I） 其中 R1a、R1b、R1c、R1d、R2a、R2b、R3、R3a、R4、R6、R7、R8、A、Z、X1 和 n 如本文所定义。还公开了与制备和使用此类化合物相关的方法，以及包含此类化合物的药物组合物。
• TRIARYL COMPOUNDS FOR TREATMENT OF PD-L1 DISEASES
  申请人：CHEMOCENTRYX, INC.

  公开号：US20200383979A1

  公开（公告）日：2020-12-10

  Compounds are provided that are useful as immunomodulators. The compounds have the Formula (I) including stereoisomers and pharmaceutically acceptable salts thereof, wherein R 1a , R 1b , R 1c , R 1d , R 2a , R 2b , R 3 , R 3a , R 4 , R 6 , R 7 , R 8 , A, Z, X 1 and n are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.