1-环己基-2-氨基甲基-吡咯烷 | 54929-86-1

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 1-环己基-2-氨基甲基-吡咯烷
• 英文名称: 1-cyclohexyl-2-aminomethyl-pyrrolidine
• 英文别名: 1-cyclohexyl-2-amino-methyl pyrrolidine；2-aminomethyl-1-cyclohexyl pyrrolidine；2-aminomethyl-1-cyclohexylpyrrolidine；(1-cyclohexylpyrrolidin-2-yl)methanamine
• CAS: 54929-86-1
• 化学式: C₁₁H₂₂N₂
• mdl: MFCD18629315
• 分子量: 182.309
• InChiKey: FWZCSDNSXJJNLH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  29.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-环己基-2-氨基甲基-吡咯烷 在 盐酸 、 氨 作用下， 以 水 为溶剂， 生成 N-(1-cyclohexyl-2-pyrrolidinyl-methyl)-2-methoxy-4-amino-5-ethylsulphonyl-benzamide
  参考文献：
  名称：

  New substituted heterocyclic benzamides, methods of preparing them and

  摘要：

  这里提供了新的替代杂环苯甲酰胺及其衍生物，这些化合物对中枢神经系统产生改变。

  公开号：

  US04673686A1
• 作为产物：
  描述：

  6-chloro-5-ethylamino-3-methoxy-pyrazine-2-carboxylic acid (1-cyclohexyl-pyrrolidin-2-ylmethyl)-amide 生成 1-环己基-2-氨基甲基-吡咯烷 、 6-chloro-5-ethylamino-3-methoxy-pyrazine-2-carboxylic acid
  参考文献：
  名称：

  Pyrazine derivatives

  摘要：

  公开了公式为##STR1##的吡嗪衍生物。在上述公式中，R.sup.1和R.sup.2，可以相同也可以不同，每个代表氢原子、卤素原子、羟基、较低的烷氧基、苯基较低的烷氧基、苯氧基、巯基、较低的烷基硫基、苯基较低的烷基硫基、苯硫基、氨基、取代氨基、较低的烷基、氨基甲酰基或磺胺基；R.sup.3代表较低的烷氧基；R.sup.4、R.sup.5和R.sup.6，可以相同也可以不同，每个代表氢原子、较低的烷基、环烷基、苯基较低的烷基或苯基；A代表较低的烷基烯基；所述的R.sup.4和A、所述的R.sup.5和A、所述的R.sup.4和R.sup.5，或所述的R.sup.5和R.sup.6可以形成一个含氮的5-或6-成员杂环环，该环可能进一步与氮原子一起含有一个杂原子，并且其药理学上可接受的无毒盐。本发明的化合物具有强大且选择性的抗呕吐活性，以及刺激胃动力的作用。

  公开号：

  US04041032A1

文献信息

• 2-Amino, 5-carbamoyl pyridine compounds
  申请人：Science Union et Cie, Societe Francaise de Racherche Medical

  公开号：US03970661A1

  公开（公告）日：1976-07-20

  Heterocyclic amides of the formula: ##SPC1## Wherein: X is N or CH; n is O or 1 and R is ##EQU1## or ##SPC2## Wherein: R.sub.1 is hydrogen or methyl, R.sub.2 and R.sub.3 which are the same, are lower alkyl or joined together, represent a polymethylenic chain from C.sub.4 to C.sub.7 optionally including an oxygen atom, and R' is saturated or unsaturated acyclic hydrocarbon radicals from C.sub.1 to C.sub.20, cycloalkyl from C.sub.3 to C.sub.7, Ar -- A-- or Ar ##EQU2## wherein: A is a single bond or a saturated or unsaturated acyclic hydrocarbon chain from C.sub.1 to C.sub.6 optionally including an oxygen atom, and Ar and R" are aromatic, alkoxy aromatic, methlenedioxy aromatic or polymethylenedioxy aromatic. These compounds are used as medicine, especially in the treatment of gastric hypersecretion, gastroduodenal ulcers and central nervous system disorders.

  该公式的杂环酰胺为：其中：X为N或CH；n为O或1，R为其中：R.sub.1为氢或甲基，R.sub.2和R.sub.3相同，为较低的烷基或结合在一起，代表一个从C.sub.4到C.sub.7的聚甲烯链，可选地包括一个氧原子，R'为饱和或不饱和的C.sub.1到C.sub.20的无环烃基，C.sub.3到C.sub.7的环烷基，Ar -- A--或Ar其中：A为单键或从C.sub.1到C.sub.6的饱和或不饱和的无环烃链，可选地包括一个氧原子，Ar和R"为芳香族，烷氧基芳香族，亚甲二氧基芳香族或聚亚甲二氧基芳香族。这些化合物被用作药物，特别用于治疗胃酸过多、胃十二指肠溃疡和中枢神经系统疾病。
• INHIBITORS OF HUMAN TUMOR-EXPRESSED CCXCKR2
  申请人：Melikian Anita

  公开号：US20100144720A1

  公开（公告）日：2010-06-10

  Pharmaceutical compositions containing organic compounds or salts thereof that serve as modulators for the SDF-1 or I-TAC chemokines are disclosed. The compounds and compositions are useful in the treatment of cancer, especially in the inhibition of cancer proliferation, growth, and metastasis. Methods of interfering with SDF-1 and/or I-TAC binding to the CCXCKR2 receptor and treating cancer using the compounds and pharmaceutical compositions of the present invention are also disclosed.

  本发明涉及含有有机化合物或其盐的制药组合物，其作为SDF-1或I-TAC趋化因子的调节剂。这些化合物和组合物在癌症治疗中特别是在抑制癌症增殖、生长和转移方面具有用途。本发明还揭示了干扰SDF-1和/或I-TAC与CCXCKR2受体结合以及使用本发明的化合物和制药组合物治疗癌症的方法。
• HAIR DYE COMPOSITION
  申请人：Kao Corporation

  公开号：EP1454617A1

  公开（公告）日：2004-09-08

  Provided are a hair bleach composition, hair dye composition and a hair treatment additive having excellent bleaching power, capable of dyeing the hair with a bright and good color, and less damaging to the hair and less irritating to the scalp. Described specifically, they are a two-part hair bleach composition, which contains (a) a nitrogenous compound represented by the following formula (1) or (2): or salt thereof, or (A) a nitrogenous compound having a solubility parameter logP in octanol/water ranging from -1 to 4 and a hydrogen peroxide remaining ratio of from 5 to 90%, or salt thereof, (b) an oxidizing agent, and optionally (c) an alkali agent and, after mixing, has a pH of from 7.5 to 12; a two-part hair dye composition comprising (a) or (A), (b) and (c) and further (d) an oxidation dye or direct dye; and an additive used therefor.

  本发明提供了一种头发漂白剂组合物、染发剂组合物和头发处理添加剂，它们具有极佳的漂白能力，能够染出鲜艳、良好的发色，而且对头发的损害较小，对头皮的刺激也较小。 具体地说，它们是一种双组分漂发组合物，其中含有 (a) 下式 (1) 或 (2) 所代表的含氮化合物： 或其盐，或(A)在辛醇/水中的溶解度参数 logP 为-1 至 4，过氧化氢剩余率为 5 至 90% 的含氮化合物，或其盐，(b)氧化剂，以及可选的(c)碱剂，混合后的 pH 值为 7.5 至 12；双组份染发组合物，包含(a)或(A)、(b)和(c)，以及(d)氧化染料或直接染料；以及用于其中的添加剂。
• Dostert; Imbert; Ancher, European Journal of Medicinal Chemistry, 1982, vol. 17, # 5, p. 437 - 444
  作者：Dostert、Imbert、Ancher、et al.

  DOI：——

  日期：——
• Synthesis and neuroleptic activity of benzamides. cis-N-(1-Benzyl-2-methylpyrrolidin-3-yl)-5-chloro-2-methoxy-4-(methylamino)benzamide and related compounds
  作者：Sumio Iwanami、Mutsuo Takashima、Yasufumi Hirata、Osamu Hasegawa、Shinji Usuda

  DOI：10.1021/jm00142a019

  日期：1981.10

  Three series of benzamides of N,N-disubstituted ethylenediamines (linear alkane-1,2-diamines), 1-substituted 2-(aminomethyl)pyrrolidines, and 1-substituted 3-aminopyrrolidines (cyclic alkane-1,2-diamines) were designed and synthesized as potential neuroleptics. All target compounds were evaluated for their inhibitory effects on apomorphine-induced stereotyped behavior in rats, and a good correlation between structure and activity was found throughout the series. In the linear series (analogues of metoclopramide), introduction of a benzyl group on the terminal nitrogen, rather than an ethyl group, and a methyl group on the p-amino group of metoclopramide both enhanced the activity. The resulting N-[2-(N-benzyl-N-methylamino)ethyl]-5-chloro-2-methoxy-4-(methylamino) benzamide(23) was about 15 times more active than metoclopramide. In the cyclic series, particularly among the benzamides of 1-benzyl-3-aminopyrrolidine, most of the compounds tested were more active than the corresponding linear benzamides. cis-N-(1-Benzyl-2-methylpyrrolidin-3-yl)-5-chloro-2-methoxy-4-(methylamino) benzamide (YM-09151-2, 55) was the most active among all of the compounds tested, being 13 and 408 times more potent than haloperidol and metoclopramide, respectively. Moreover, compound 55 exhibited a fairly high ratio of antistereotypic activity to cataleptogenicity compared with haloperidol and metoclopramide. It is expected that compound 55 may be used as a potent drug with few side effects in the treatment of psychosis.