1-Ethylthioisochinolin | 70259-76-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: 1-Ethylthioisochinolin
• 英文别名: 1-ethylsulfanyl-isoquinoline；1-(Ethylsulfanyl)isoquinoline；1-ethylsulfanylisoquinoline
• CAS: 70259-76-6
• 化学式: C₁₁H₁₁NS
• 分子量: 189.281
• InChiKey: KXHBLBNJTOIXPE-UHFFFAOYSA-N

物化性质

• 沸点：
  128-132 °C(Press: 1 Torr)
• 密度：
  1.15±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  38.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3-Bromo-2-cyano-1,4-diethylthio-1,2,3,4-tetrahydroisoquinoline 、 硼氢化钠 以70%的产率得到
  参考文献：
  名称：

  SUGIURA MICHIHARU; HAMADA YOSHIKI, YAKUGAKU DZASSI, YAKUGAKU ZASSNI, J. PHARM. SOS. JAR., 1979, 99, NO 6, 55+

  摘要：

  DOI：

文献信息

• PHARMACEUTICAL USE OF SUBSTITUTED AMIDES
  申请人：Andersen Henrik Sune

  公开号：US20090124598A1

  公开（公告）日：2009-05-14

  The use of substituted amides for modulating the activity of 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) and the use of these compounds as pharmaceutical compositions, are described. Also a novel class of substituted amides, their use in therapy, pharmaceutical compositions comprising the compounds, as well as their use in the manufacture of medicaments are described. The present compounds are modulators and more specifically inhibitors of the activity of 11βHSD1 and may be useful in the treatment of a range of medical disorders where a decreased intracellular concentration of active glucocorticoid is desirable.

  描述了使用替代酰胺来调节11β-羟基类固醇脱氢酶1（11βHSD1）活性以及将这些化合物用作药物组合物的用途。还描述了一类新型的替代酰胺，它们在治疗中的应用，包含这些化合物的药物组合物，以及它们在制造药物中的应用。目前的化合物是11βHSD1活性的调节剂，更具体地是抑制剂，并且可能在治疗一系列医学疾病中有用，其中降低细胞内活性糖皮质激素浓度是可取的。
• Pharmaceutical use of fused 1,2,4-triazoles
  申请人：Andersen Sune Henrik

  公开号：US20060106008A1

  公开（公告）日：2006-05-18

  The use of fused 1,2,4-triazoles for modulating the activity of 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) and the use of these compounds as pharmaceutical compositions has been described. Also a novel class of fused 1,2,4-triazoles, their use in therapy, pharmaceutical compositions comprising the compounds, as well as their use in the manufacture of medicaments has been described. The present compounds are modulators and more specifically inhibitors of the activity of 11βHSD1 and may be useful in the treatment, prevention and/or prophylaxis of a range of medical disorders where a decreased intracellular concentration of active glucocorticoid is desirable.

  使用熔合的1,2,4-三唑类物质来调节11β-羟基类固醇脱氢酶1型（11βHSD1）的活性以及将这些化合物用作制药组合物已经被描述。同时，还描述了一种新的熔合的1,2,4-三唑类物质，它们在治疗中的使用、包含这些化合物的制药组合物以及它们在制造药物方面的使用。这些化合物是调节剂，更具体地说是11βHSD1的抑制剂，可能在治疗、预防和/或预防一系列医学疾病中有用，其中需要降低细胞内活性糖皮质激素的浓度。
• Pharmaceutical use of substituted amides
  申请人：Andersen Sune Henrik

  公开号：US20060111366A1

  公开（公告）日：2006-05-25

  The use of substituted amides for modulating the activity of 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) and the use of these compounds as pharmaceutical compositions, are described. Also a novel class of substituted amides, their use in therapy, pharmaceutical compositions comprising the compounds, as well as their use in the manufacture of medicaments are described. The present compounds are modulators and more specifically inhibitors of the activity of 11βHSD1 and may be useful in the treatment, prevention and/or prophylaxis of a range of medical disorders where a decreased intracellular concentration of active glucocorticoid is desirable.

  本文介绍了使用取代酰胺来调节11β-羟化甾体脱氢酶1型（11βHSD1）的活性以及将这些化合物用作制药组合物的方法。还介绍了一类新型的取代酰胺，它们在治疗中的应用、包含这些化合物的制药组合物以及它们在药物制剂制造中的应用。这些化合物是11βHSD1的调节剂，更具体地说是抑制剂，可用于治疗、预防和/或预防一系列需要降低活性糖皮质激素细胞内浓度的医学疾病。
• Amide Derivatives and Pharmaceutical Use Thereof
  申请人：Andersen Henrik Sune

  公开号：US20090264414A1

  公开（公告）日：2009-10-22

  The use of substituted amides for modulating the activity of 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) and the use of these compounds as pharmaceutical compositions, are described. Also a novel class of substituted amides, their use in therapy, pharmaceutical compositions comprising the compounds, as well as their use in the manufacture of medicaments are described. The present compounds are modulators and more specifically inhibitors of the activity of 11βHSD1 and may be useful in the treatment, prevention and/or prophylaxis of a range of medical disorders where a decreased intracellular concentration of active glucocorticoid is desirable.

  本文描述了使用取代酰胺来调节11β-羟化类固醇脱氢酶1型（11βHSD1）活性以及这些化合物作为药物组分的用途。还描述了一类新型的取代酰胺，它们在治疗中的用途，包括含有这些化合物的药物组分以及它们在制造药物中的用途。这些化合物是调节剂，更具体地说是11βHSD1活性的抑制剂，可用于治疗、预防和/或预防一系列医学疾病，其中降低细胞内活性糖皮质激素的浓度是可取的。
• 11BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 ACTIVE COMPOUNDS
  申请人：Ebdrup Soren

  公开号：US20100009968A1

  公开（公告）日：2010-01-14

  The use of substituted amides for modulating the activity of 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) and the use of these compounds as pharmaceutical compositions, are described. Also a novel class of substituted amides, of the general formula I. Their use in therapy, pharmaceutical compositions comprising the compounds, as well as their use in the manufacture of medicaments are described. The present compounds are modulators and more specifically inhibitors of the activity of 11βHSDI and may be useful in the treatment of a range of medical disorders where a decreased intracellular concentration of active glucocorticoid is desirable.

  本文描述了使用取代酰胺来调节11β-羟基类固醇脱氢酶1型（11βHSD1）活性的方法，以及这些化合物作为药物组成物的用途。还介绍了一类新型的取代酰胺，其一般式为I。描述了它们在治疗中的应用、包含这些化合物的药物组成物，以及它们在制造药物方面的用途。这些化合物是11βHSDI活性的调节剂，更具体地说是抑制剂，可能在治疗需要降低细胞内活性糖皮质激素浓度的一系列医学疾病中有用。