6-{(R)-5-[3-(7-methoxy-2-oxo-2H-quinoxalin-1-ylmethyl)-azetidin-1-ylmethyl]-2-oxo-oxazolidin-3-yl}-4H-benzo[1,4]thiazin-3-one | 1221275-57-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 6-{(R)-5-[3-(7-methoxy-2-oxo-2H-quinoxalin-1-ylmethyl)-azetidin-1-ylmethyl]-2-oxo-oxazolidin-3-yl}-4H-benzo[1,4]thiazin-3-one
• 英文别名: (5R)-5-[[3-[(7-methoxy-2-oxoquinoxalin-1-yl)methyl]azetidin-1-yl]methyl]-3-(3-oxo-4H-1,4-benzothiazin-6-yl)-1,3-oxazolidin-2-one
• CAS: 1221275-57-5
• 化学式: C₂₅H₂₅N₅O₅S
• 分子量: 507.57
• InChiKey: AZUAJRVHGCTCPW-GOSISDBHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  36
• 可旋转键数：
  6
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  129
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• OXAZOLIDINYL ANTIBIOTICS
  申请人：Actelion Pharmaceuticals Ltd

  公开号：EP2344485B1

  公开（公告）日：2017-03-22
• US8507478B2
  申请人：——

  公开号：US8507478B2

  公开（公告）日：2013-08-13
• [EN] OXAZOLIDINYL ANTIBIOTICS<br/>[FR] ANTIBIOTIQUES OXAZOLIDINYLE
  申请人：ACTELION PHARMACEUTICALS LTD

  公开号：WO2010041218A2

  公开（公告）日：2010-04-15

  The invention relates to antibacterial compounds of Formula (I) wherein R1 is alkoxy or halogen; U and V each independently are CH or N; "----" is a bond or is absent; W is CH or N or, when "----" is absent, W is CH2 or NH, with the proviso that U, V and W are not all N; A is a bond or CH2; R2 is H or, provided A is CH2, may also be OH; m and n each independently are 0 or 1; D is CH2 or a bond; G represents a phenyl group substituted once or twice in the meta and/or para position (s) by substituents selected from alkyl, (C1-C3)alkyl and halogen, or G is a group G1 or G2 wherein Z1, Z2 and Z3 may each represent CH or N; X is N or CH and Q is O or S; it being understood that if m and n each are 0, then A is CH2; and salts of such compounds.