4-(4-Bromo-phenyl)-1-(indane-5-sulfonyl)-2-methoxy-4,5-dihydro-1H-imidazole | 185098-56-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四氢异喹啉
• 英文名称: 4-(4-Bromo-phenyl)-1-(indane-5-sulfonyl)-2-methoxy-4,5-dihydro-1H-imidazole
• CAS: 185098-56-0
• 化学式: C₁₉H₁₉BrN₂O₃S
• 分子量: 435.341
• InChiKey: RUMGORUAKLIRLX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.69
• 重原子数：
  26.0
• 可旋转键数：
  3.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  58.97
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  4-(4-Bromo-phenyl)-1-(indane-5-sulfonyl)-2-methoxy-4,5-dihydro-1H-imidazole 在 盐酸 作用下， 以 乙醚 为溶剂， 生成 4-(4-bromophenyl)-1-(2,3-dihydro-1H-inden-5-ylsulfonyl)imidazolidin-2-one
  参考文献：
  名称：

  Synthesis and evaluation of cytotoxic activity of novel arylsulfonylimidazolidinones

  摘要：

  Synthesis of novel arylsulfonylimidazolidinones 3 and 4 containing sulfonylurea pharmacophore and evaluation of their in vitro cytotoxicity against human cell lines were investigated. As a result, a series of 4-phenyl-1(N)-arylsulfonylimidazolidinones have been found to be the potential anticancer agent. Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/0960-894x(96)00463-5
• 作为产物：
  描述：

  [2-bromo-1-(4-bromophenyl)ethyl]cyanamide 在 盐酸 、 碳酸氢钠 、 sodium carbonate 作用下， 生成 4-(4-Bromo-phenyl)-1-(indane-5-sulfonyl)-2-methoxy-4,5-dihydro-1H-imidazole
  参考文献：
  名称：

  Synthesis and evaluation of cytotoxic activity of novel arylsulfonylimidazolidinones

  摘要：

  Synthesis of novel arylsulfonylimidazolidinones 3 and 4 containing sulfonylurea pharmacophore and evaluation of their in vitro cytotoxicity against human cell lines were investigated. As a result, a series of 4-phenyl-1(N)-arylsulfonylimidazolidinones have been found to be the potential anticancer agent. Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/0960-894x(96)00463-5