N-(3-{4-[3-chloro-4-(pyridin-2-ylmethoxy)-phenylamino]-7-methoxy-quinazolin-6-yloxy}-propyl)-N'-cyano-N''-(2-dimethylamino-ethyl)-N''-methylguanidine | 697299-92-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: N-(3-{4-[3-chloro-4-(pyridin-2-ylmethoxy)-phenylamino]-7-methoxy-quinazolin-6-yloxy}-propyl)-N'-cyano-N''-(2-dimethylamino-ethyl)-N''-methylguanidine
• 英文别名: N-(3-{4-[3-chloro-4-(pyridin-2-ylmethoxy)phenylamino]-7-methoxyquinazolin-6-yloxy}propyl)-N'-cyano-N"-(2-dimethylaminoethyl)-N"-methylguanidine；2-[3-[4-[3-Chloro-4-(pyridin-2-ylmethoxy)anilino]-7-methoxyquinazolin-6-yl]oxypropyl]-3-cyano-1-[2-(dimethylamino)ethyl]-1-methylguanidine
• CAS: 697299-92-6
• 化学式: C₃₁H₃₆ClN₉O₃
• 分子量: 618.138
• InChiKey: JUSMIWSQHGRZOR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  44
• 可旋转键数：
  16
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  133
• 氢给体数：
  2
• 氢受体数：
  10

文献信息

• CYANOGUANIDINES AND CYANOAMIDINES AS ERBB2 AND EGFR INHIBITORS
  申请人：Wallace Eli

  公开号：US20090012290A1

  公开（公告）日：2009-01-08

  Cyanoguanidine quinazoline and cyanoamidine quinazolamine derivatives that are useful in the treatment of hyperproliferative diseases are disclosed. Methods of treating hyperproliferative diseases in mammals are also disclosed.

  本发明公开了用于治疗增殖性疾病的氰基胍喹嗪和氰基胍喹唑衍生物。还公开了治疗哺乳动物增殖性疾病的方法。
• EP1567506A4
  申请人：——

  公开号：EP1567506A4

  公开（公告）日：2007-06-20
• US7488823B2
  申请人：——

  公开号：US7488823B2

  公开（公告）日：2009-02-10
• US8088766B2
  申请人：——

  公开号：US8088766B2

  公开（公告）日：2012-01-03
• [EN] CYANOGUANIDINES AND CYANOAMIDINES AS ERBB2 AND EGFR INHIBITORS<br/>[FR] CYANOGUANIDINES ET CYANOAMIDINES UTILISEES COMME INHIBITEURS DE ERBB2 ET EGFR
  申请人：ARRAY BIOPHARMA INC

  公开号：WO2004046101A2

  公开（公告）日：2004-06-03

  Cyanoguanidine quinazoline and cyanoamidine quinazolamine derivatives that are useful in the treatment of hyperproliferative diseases are disclosed. Use of the compounds of the invention to manufacture therapeutic compositions for the treatment of hyperproliferative diseases in mammals is also disclosed.