3-[5-[(naphthalen-1-yloxy)methyl]-2-thioxo-1,3,4-oxadiazol-3(2H)-yl]propanenitrile | 1248497-98-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 3-[5-[(naphthalen-1-yloxy)methyl]-2-thioxo-1,3,4-oxadiazol-3(2H)-yl]propanenitrile
• 英文别名: 3-[5-(naphthalen-1-yloxymethyl)-2-sulfanylidene-1,3,4-oxadiazol-3-yl]propanenitrile
• CAS: 1248497-98-4
• 化学式: C₁₆H₁₃N₃O₂S
• 分子量: 311.364
• InChiKey: BIYOOZKDXXTQFX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  89.9
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  3-[5-[(naphthalen-1-yloxy)methyl]-2-thioxo-1,3,4-oxadiazol-3(2H)-yl]propanenitrile 在 一水合肼 作用下， 以 乙醇 为溶剂， 反应 4.0h， 以70%的产率得到3-[5-[(naphthalen-1-yloxy)methyl]-2-thioxo-1,3,4-oxadiazol-3(2H)-yl]propanimidic acid hydrazide
  参考文献：
  名称：

  Synthesis and antiviral evaluation of new 2,5-disubstituted 1,3,4-oxadiazole derivatives and their acyclic nucleoside analogues

  摘要：

  A number of new 5-[(naphthalen-1-yloxy)-methyl]-1,3,4-oxadiazole derivatives were synthesized. Sugar 2-[5-[(naphthalen-1-yloxy)methyl]-1,3,4-oxadiazol-2-ylthio]acetohydrazones were prepared by condensation of the hydrazide with the corresponding monosaccharides. Cyclization of the sugar hydrazones with acetic anhydride afforded the substituted oxadiazoline derivatives. The synthesized compounds displayed different degrees of antiviral activities or inhibitory actions against HCV and HIV viruses.

  DOI：

  10.1007/s00706-010-0360-y
• 作为产物：
  描述：

  1-(萘氧基)乙酸肼 在 三乙胺 、 potassium hydroxide 作用下， 以 乙醇 为溶剂， 反应 3.0h， 生成 3-[5-[(naphthalen-1-yloxy)methyl]-2-thioxo-1,3,4-oxadiazol-3(2H)-yl]propanenitrile
  参考文献：
  名称：

  Synthesis and antiviral evaluation of new 2,5-disubstituted 1,3,4-oxadiazole derivatives and their acyclic nucleoside analogues

  摘要：

  A number of new 5-[(naphthalen-1-yloxy)-methyl]-1,3,4-oxadiazole derivatives were synthesized. Sugar 2-[5-[(naphthalen-1-yloxy)methyl]-1,3,4-oxadiazol-2-ylthio]acetohydrazones were prepared by condensation of the hydrazide with the corresponding monosaccharides. Cyclization of the sugar hydrazones with acetic anhydride afforded the substituted oxadiazoline derivatives. The synthesized compounds displayed different degrees of antiviral activities or inhibitory actions against HCV and HIV viruses.

  DOI：

  10.1007/s00706-010-0360-y