Acetamide, N-(trans-4-aminocyclohexyl)-, mono(trifluoroacetate) | 873537-24-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: Acetamide, N-(trans-4-aminocyclohexyl)-, mono(trifluoroacetate)
• 英文别名: N-(trans-4-aminocyclohexyl)acetamide trifluoroacetic acid salt
• CAS: 873537-24-7
• 化学式: C₂HF₃O₂*C₈H₁₆N₂O
• 分子量: 270.252
• InChiKey: KOSZSHIINSGPHL-KMMPGQJCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.03
• 重原子数：
  18.0
• 可旋转键数：
  1.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  92.42
• 氢给体数：
  3.0
• 氢受体数：
  3.0

反应信息

• 作为产物：
  描述：

  2-Methyl-2-propanyl (trans-4-acetamidocyclohexyl)carbamate 、 三氟乙酸 以 二氯甲烷 为溶剂， 反应 0.5h， 以84%的产率得到Acetamide, N-(trans-4-aminocyclohexyl)-, mono(trifluoroacetate)
  参考文献：
  名称：

  THIENOPYRAZOLE DERIVATIVE HAVING PDE7 INHIBITORY ACTIVITY

  摘要：

  公开号：

  EP1775298B1

文献信息

• HETEROCYCLIC COMPOUNDS, MEDICAMENTS CONTAINING THEM, USE AND PROCESSES FOR THE PREPARATION THEREOF
  申请人：HECKEL Armin

  公开号：US20150011535A1

  公开（公告）日：2015-01-08

  The present invention relates to compounds of general formula (I) and the tautomers and the salts thereof, particularly the pharmaceutically acceptable salts thereof with inorganic or organic acids and bases, which have valuable pharmacological properties, particularly an inhibitory effect on epithelial sodium channels, and the use thereof for the treatment of diseases, particularly diseases of the lungs and airways.

  本发明涉及通式（I）的化合物，以及其互变异构体和盐，特别是其与无机或有机酸和碱形成的药用可接受盐，具有有价值的药理学特性，特别是对上皮钠通道具有抑制作用，并且用于治疗疾病，特别是肺部和气道疾病。
• [EN] AMILORIDE-TYPE COMPOUNDS AS INHIBITORS IN EPITHELIAL SODIUM CHANNELS FOR THE TREATMENT OF DISEASES OF THE LUNGS AND AIRWAYS<br/>[FR] COMPOSÉS DE TYPE AMILORIDE EN TANT QU'INHIBITEURS DE CANAUX SODIUM ÉPITHÉLIAUX POUR LE TRAITEMENT DE MALADIES DES POUMONS ET DES VOIES RESPIRATOIRES
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2015003958A1

  公开（公告）日：2015-01-15

  P01-2935/FF 88/88 -88- ABSTRACT The present invention relates to compounds of general formula (I) R N NNH 2 N O N H NH 2 NH 2 X A' A (I) and the tautomersand the salts thereof, particularly the pharmaceutically acceptable salts thereof with inorganic or organic acids and bases, which have valuable pharmacological properties, particularly an inhibitory effect on epithelial sodium channels, the use thereof for the treatmentof diseases, particularly diseases of the lungs and airways.

  本发明涉及一般式（I）R N NNH 2 N O N H NH 2 NH 2 X A' A（I）的化合物及其互变异构体和盐，特别是其与无机或有机酸和碱形成的药用可接受盐，具有有价值的药理特性，尤其是对上皮钠通道具有抑制作用，用于治疗疾病，特别是肺部和呼吸道疾病。
• SUBSTITUTED DIAMINOCARBOXAMIDE AND DIAMINOCARBONITRILE PYRIMIDINES, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH
  申请人：Bennett Brydon L.

  公开号：US20130029987A1

  公开（公告）日：2013-01-31

  Provided herein are Diaminopyrimidine Compounds having the following structures: wherein R 1 , R 2 , R 3 , and R 4 are as defined herein, compositions comprising an effective amount of a Diaminopyrimidine Compound, and methods for treating or preventing liver fibrotic disorders or a condition treatable or preventable by inhibition of a JNK pathway.

  本文提供以下结构的二氨基嘧啶化合物：其中R1、R2、R3和R4的定义如下，在有效量的二氨基嘧啶化合物组成物中，以及用于治疗或预防肝纤维化疾病或可通过抑制JNK途径治疗或预防的疾病的方法。
• Thienopyrazole Derivative Having PDE7 Inhibitory Activity
  申请人：Inoue Hidekazu

  公开号：US20090131413A1

  公开（公告）日：2009-05-21

  To provide thienopyrazole derivatives inhibiting PDE 7 selectively, and therefore, enhance cellular cAMP level. Consequently, the compound is useful for treating various kinds of disease such as allergic diseases, inflammatory diseases or immunologic diseases. The compound is thienopyrazole compound represented by the following formula (I): [wherein, especially, R 1 is a cyclohexyl, a cycloheptyl group or a tetrahydropyranyl group; R 2 is methyl; R 3 is a hydrogen atom; and R 4 is a group: —CONR 5 R 6 (in which any one of R 5 and R 6 is a hydrogen atom)].

  为了提供选择性抑制PDE 7的噻唑吡啶衍生物，从而增强细胞cAMP水平。因此，该化合物可用于治疗各种疾病，如过敏性疾病、炎症性疾病或免疫性疾病。该化合物是由以下式子(I)表示的噻唑吡啶化合物：[其中，特别地，R1是环己基、环庚基或四氢吡喃基；R2是甲基；R3是氢原子；R4是一个基团：—CONR5R6（其中R5和R6中的任何一个是氢原子）]。
• Thienopyrazole derivatives having PDE7 inhibitory activity
  申请人：Daiichi Sankyo Company, Limited

  公开号：EP2433943A1

  公开（公告）日：2012-03-28

  To provide thienopyrazole derivatives inhibiting PDE 7 selectively, and therefore, enhance cellular cAMP level. Consequently, the compound is useful for treating various kinds of disease such as allergic diseases, inflammatory diseases or immunologic diseases. The compound is thienopyrazole compound represented by the following formula (I): [wherein, especially, R1 is a cyclohexyl, a cycloheptyl group or a tetrahydropyranyl group; R2 is methyl; R3 is a hydrogen atom; and R4 is a group: -CONR5R6 (in which any one of R5 and R6 is a hydrogen atom)].

  提供选择性抑制 PDE 7 并因此提高细胞 cAMP 水平的噻吩并吡唑衍生物。因此，该化合物可用于治疗各种疾病，如过敏性疾病、炎症性疾病或免疫性疾病。该化合物是由下式（I）代表的噻吩并唑化合物： [其中，R1 特别是环己基、环庚基或四氢吡喃基；R2 是甲基；R3 是氢原子；R4 是基团：-CONR5R6（其中 R5 和 R6 中的任一个是氢原子）]。