2-amino-4-methyl-6-(4-morpholinyl)pyrimidine-3-oxide | 80142-49-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-amino-4-methyl-6-(4-morpholinyl)pyrimidine-3-oxide
• 英文别名: 2-amino-4-methyl-6-morpholinopyrimidine 3-oxide
• CAS: 80142-49-0
• 化学式: C₉H₁₄N₄O₂
• 分子量: 210.236
• InChiKey: BTMRTXBVAZHETG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.56
• 重原子数：
  15.0
• 可旋转键数：
  1.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  78.32
• 氢给体数：
  1.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  2-amino-4-methyl-6-(4-morpholinyl)pyrimidine-3-oxide 以 氯仿 为溶剂， 以28%的产率得到2-amino-6-methyl-4-(4-morpholinyl)-1-(sulfooxy)-pyrimidinium hydroxide
  参考文献：
  名称：

  Sulfooxy-pyrimidinium, -pyridinium, and -triazinium hydroxide inner salts

  摘要：

  本发明提供了新的取代磺酰氧基嘧啶、吡啶和三嗪羧酸内盐。这些化合物对于治疗高血压和周围血管疾病很有用。它们通过将相应的氨基嘧啶、氨基三嗪和氨基吡啶N-氧化物与潜在的硫酸盐源（如吡啶-三氧化硫复合物、三乙胺-三氧化硫复合物、氯磺酸或氯磺酰氯）反应而形成。

  公开号：

  US04287338A1

文献信息

• Pyrimidine and triazine 3-oxide sulfates: a new family of vasodilators
  作者：John M. McCall、James W. Aiken、Constance G. Chidester、Donald W. DuCharme、Michael G. Wendling

  DOI：10.1021/jm00366a030

  日期：1983.12

  4-diamino-6-piperidinylpyrimidine 3-oxide and 2,4-diamino-6-(diallylamino)triazine 3-oxide) react with sources of sulfur trioxide, such as sulfur trioxide trimethylamine or chlorosulfuryl chloride, to yield the corresponding heterocyclic O-sulfates. These sulfates are inner salts with unusual physical properties. The structure of the O-sulfate of 2,4-diamino-6-piperidinylpyrimidine 3-oxide was confirmed by X-ray

  二-和三氨基嘧啶3-氧化物（例如2,4-二氨基-6-哌啶基嘧啶3-氧化物和2,4-二氨基-6-（二烯丙基氨基）三嗪3-氧化物）与三氧化硫源（例如三氧化硫）反应三甲胺或氯磺酰氯，得到相应的杂环O-硫酸盐。这些硫酸盐是具有异常物理性质的内盐。通过X射线确认2，4-二氨基-6-哌啶基嘧啶3-氧化物的O-硫酸盐的结构。这些O-硫酸盐是降压药。它们显然是通过直接的血管扩张作用。
• HAIR TREATMENT COMPOSITION AND HAIR COSMETIC FOR DAMAGED HAIR
  申请人：Meiji Seika Kaisha, Ltd.

  公开号：EP1602354A1

  公开（公告）日：2005-12-07

  The present invention intends to provide a composition for hair treatment containing γ-polyglutamic acid or a salt thereof, a hair cosmetic for damaged hair containing such a composition, and their uses. The composition for hair treatment containing γ-polyglutamic acid or a salt thereof and the hair cosmetic for damaged hair of the present invention have excellent improvement effects on the strength and frictional force of hair, so that they can provide tension, elasticity, or the like to damage hair to prevent or alleviate split hair and broken hair as well as improvements in combing and touch. Furthermore, they also exert effects of moisture retention inherent to γ-polyglutamic acid or a salt thereof, preventing or improving effects on the generation of dandruff on the basis of such effects, preventing effects on the feeling of stickiness or creak, and various effectiveness including appropriate residual tendency to hair in a simultaneous manner, respectively.

  本发明旨在提供一种含有γ-聚谷氨酸或其盐的头发治疗组合物、一种含有这种组合物的用于受损头发的护发化妆品及其用途。本发明的含有γ-聚谷氨酸或其盐的头发治疗组合物和用于受损头发的护发化妆品对头发的强度和摩擦力有很好的改善效果，因此它们可以为受损头发提供张力、弹性等，以防止或减轻头发分叉和断裂，并改善梳理和触感。此外，它们还能分别发挥γ-聚谷氨酸或其盐固有的保湿效果、在此基础上防止或改善头皮屑产生的效果、防止粘腻感或吱吱作响的效果，以及包括同时对头发产生适当残留倾向在内的各种功效。
• Cosmetic composition and production thereof
  申请人：Kawasaki Yuji

  公开号：US20060018867A1

  公开（公告）日：2006-01-26

  It has been desired to develop a highly preservative and antibacterial cosmetic composition that can easily be applied to both emulsion and non-emulsion type cosmetics. It has also been desired to develop a method of improving a preservative and/or antibacterial effect(s) of a cosmetic composition comprising polyorganosiloxane-containing epsilon-polylysine and thereby reducing the amount of antibacterial preservative agent to be used. There is provided a cosmetic composition comprising one or a combination of two or more of polyorganosiloxane-containing epsilon-polylysine compounds obtained by reacting epsilon-polylysine with polyorganosiloxane or a physiologically acceptable salt thereof, and polyhydric alcohol.

  人们一直希望开发一种高防腐性和抗菌性的化妆品组合物，这种组合物既可用于乳液型化妆品，也可用于非乳液型化妆品。此外，还希望开发一种方法，以改善含有聚有机硅氧烷的ε-聚赖氨酸的化妆品组合物的防腐和/或抗菌效果，从而减少抗菌防腐剂的用量。本发明提供了一种化妆品组合物，该组合物包含一种或两种以上的含聚有机硅氧烷的ε-聚赖氨酸化合物的组合，这些ε-聚赖氨酸化合物是通过ε-聚赖氨酸与聚有机硅氧烷或其生理上可接受的盐以及多元醇反应而得到的。
• Hair treatment composition and hair cosmetic for damaged hair
  申请人：Hasebe Kouhei

  公开号：US20060165636A1

  公开（公告）日：2006-07-27

  The present invention intends to provide a composition for hair treatment containing γ-polyglutamic acid or a salt thereof, a hair cosmetic for damaged hair containing such a composition, and their uses. The composition for hair treatment containing γ-polyglutamic acid or a salt thereof and the hair cosmetic for damaged hair of the present invention have excellent improvement effects on the strength and frictional force of hair, so that they can provide tension, elasticity, or the like to damage hair to prevent or alleviate split hair and broken hair as well as improvements in combing and touch. Furthermore, they also exert effects of moisture retention inherent to γ-polyglutamic acid or a salt thereof, preventing or improving effects on the generation of dandruff on the basis of such effects, preventing effects on the feeling of stickiness or creak, and various effectiveness including appropriate residual tendency to hair in a simultaneous manner, respectively.

  本发明旨在提供一种含有γ-聚谷氨酸或其盐的头发治疗组合物、一种含有这种组合物的用于受损头发的护发化妆品及其用途。本发明的含有γ-聚谷氨酸或其盐的头发治疗组合物和用于受损头发的护发化妆品对头发的强度和摩擦力有很好的改善效果，因此它们可以为受损头发提供张力、弹性等，以防止或减轻头发分叉和断裂，并改善梳理和触感。此外，它们还能分别发挥γ-聚谷氨酸或其盐固有的保湿效果、在此基础上防止或改善头皮屑产生的效果、防止粘腻感或吱吱作响的效果，以及包括同时对头发产生适当残留倾向在内的各种功效。
• Use of polyglutamic acid or its salts
  申请人：Meiji Seika Kaisha Ltd.

  公开号：EP1602354B1

  公开（公告）日：2008-11-05