N-[4-[[(2-氨基-3,4-二氢-4-氧代-6-蝶啶基)甲基]氨基]苯甲酰基]-L-谷氨酸钠盐(1:1) | 6484-89-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 蝶啶及其衍生物
• 中文名称: N-[4-[[(2-氨基-3,4-二氢-4-氧代-6-蝶啶基)甲基]氨基]苯甲酰基]-L-谷氨酸钠盐(1:1)
• 英文名称: Folic acid (sodium)
• CAS: 6484-89-5
• 化学式: C19H19N7NaO6
• 分子量: 464.4
• InChiKey: BKZXCQHKUDXYEJ-YDALLXLXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.43
• 重原子数：
  33
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  209
• 氢给体数：
  6
• 氢受体数：
  9

文献信息

• Multi-functional ionic liquid compositions for overcoming polymorphism and imparting improved properties for active pharmaceutical, biological, nutritional, and energetic ingredients
  申请人：Rogers D. Robin

  公开号：US20070093462A1

  公开（公告）日：2007-04-26

  Disclosed are ionic liquids and methods of preparing ionic liquid compositions of active pharmaceutical, biological, nutritional, and energetic ingredients. Also disclosed are methods of using the compositions described herein to overcome polymorphism, overcome solubility and delivery problems, to control release rates, add functionality, enhance efficacy (synergy), and improve ease of use and manufacture.

  揭示了离子液体及制备活性药物、生物、营养和能量成分的离子液体组合物的方法。还揭示了利用本文描述的组合物的方法，以克服多型性、克服溶解度和输送问题、控制释放速率、增加功能性、增强功效（协同作用）以及改善易用性和制造工艺。
• Compositions and methods for treating an arthritic condition
  申请人：——

  公开号：US20020094970A1

  公开（公告）日：2002-07-18

  The present invention features compositions and methods for the treatment of an arthritic condition. The compositions contain a reduced folate compound and a cobalamin compound.

  本发明的特点是提供了一种治疗关节炎的组合物和方法。该组合物包含一种还原型叶酸化合物和一种钴胺素化合物。
• Multi-Functional Ionic Liquid Compositions for Overcoming Polymorphism and Imparting Improved Properties for Active Pharmaceutical, Biological, Nutritional, and Energetic Ingredients
  申请人：Rogers Robin D.

  公开号：US20120264605A1

  公开（公告）日：2012-10-18

  Disclosed are ionic liquids and methods of preparing ionic liquid compositions of active pharmaceutical, biological, nutritional, and energetic ingredients. Also disclosed are methods of using the compositions described herein to overcome polymorphism, overcome solubility and delivery problems, to control release rates, add functionality, enhance efficacy (synergy), and improve ease of use and manufacture.

  本发明涉及离子液体和制备含有活性制药、生物、营养和能量成分的离子液体组合物的方法。同时，本发明还涉及使用所述组合物的方法，以克服多晶性、克服溶解度和输送问题、控制释放速率、增加功能、增强功效（协同作用）和改善使用和制造的便利性。
• Electrochemical controlled release drug delivery system
  申请人：REGENTS OF THE UNIVERSITY OF MINNESOTA

  公开号：EP0182765A2

  公开（公告）日：1986-05-28

  A method is disclosed for the controlled delivery of an ionic bioactive chemical into a physiological medium comprising ionically binding the chemical to redox sites on a charged polymer and releasing the bound chemical into the medium by neutralizing the charge on the polymer.

  本发明公开了一种将离子型生物活性化学物质有控制地输送到生理介质中的方法，包括将化学物质离子结合到带电聚合物上的氧化还原位点，并通过中和聚合物上的电荷将结合的化学物质释放到介质中。
• Stable injectable pharmaceutical formulation for folic acid and leucovorin salts and method
  申请人：AMERICAN CYANAMID COMPANY

  公开号：EP0416232A2

  公开（公告）日：1991-03-13

  Injectable aqueous compositions comprising folic acid and leucovorin and their salts, optionally including benzyl alcohol, sodium chloride and agents for adjusting pH are stabilized and buffered in the range of 6 to 10 by adding a combination of tromethamine and monothioglycerol. Such compositions remain stable for prolonged periods even when exposed to sunlight.

  叶酸和亮菌甲素及其盐类组成的可注射水溶液组合物，可选择包括苯甲醇、氯化钠和调节 pH 值的药剂，通过添加三甲胺和单硫代甘油的组合物，可稳定和缓冲在 6-10 的范围内。即使暴露在阳光下，这种组合物也能长时间保持稳定。