1-[(2'-carboxybiphenyl-4-yl)methyl]-2-(1-trans-butenyl)-4-chloroimidazole-5-carboxaldehyde | 129722-03-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-[(2'-carboxybiphenyl-4-yl)methyl]-2-(1-trans-butenyl)-4-chloroimidazole-5-carboxaldehyde
• 英文别名: EXP 9654；2-(1E-Butenyl)-4-chloro-1-[(2'-carboxybiphenyl-4-yl)methyl]-imidazole-5-carboxaldehyde；2-[4-[[2-[(E)-but-1-enyl]-4-chloro-5-formylimidazol-1-yl]methyl]phenyl]benzoic acid
• CAS: 129722-03-8
• 化学式: C₂₂H₁₉ClN₂O₃
• 分子量: 394.857
• InChiKey: AMVRXQXLMVPAGT-FPYGCLRLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  28
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  72.2
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Use of an angiotensin II receptor antagonist for the preparation of drugs to increase the survival rate of renal transplant patients
  申请人：MERCK SHARP & DOHME (Italia) S.p.A.

  公开号：US20020115702A1

  公开（公告）日：2002-08-22

  The present invention relates to the use, for the preparation of drugs to increase the survival rate of transplant patients, including renal and heart transplant patients, of a therapeutically effective amount of an angiotension II receptor antagonist compound, such as the class of substituted imidazoles represented by formula (I) and in particular by losartan potassium, 2-butyl-4-chloro-[(2′-tetrazol-5-yl)biphenyl-4-il]methyl]-5-(hydroxymethyl)imidazole potassium salt.

  本发明涉及使用治疗有效量的血管紧张素II受体拮抗剂化合物，如由式(I)所代表的取代咪唑类化合物，特别是洛卡特普钾，2-丁基-4-氯-[2'-四唑-5-基]联苯-4-甲基-5-(羟甲基)咪唑钾盐，用于制备增加移植患者生存率的药物，包括肾脏和心脏移植患者。
• Angiotensin II receptor blocking imidazoles
  申请人：E.I. DU PONT DE NEMOURS AND COMPANY

  公开号：EP0253310A2

  公开（公告）日：1988-01-20

  Substituted imidazoles such as are useful as angiotensin II blockers. These compounds have activity in treating hypertension and congestive heart failure.

  这些化合物具有治疗高血压和充血性心力衰竭的活性。
• Angiotensin II receptor blocking imidazoles and combinations thereof with diuretics and NSaids
  申请人：E.I. DU PONT DE NEMOURS AND COMPANY

  公开号：EP0324377A2

  公开（公告）日：1989-07-19

  The invention encompasses a pharmaceutical composition comprising a diuretic or a non-steroidal antiinflammatory drug, a pharmaceutical suitable carrier and an antihypertensive and processes for production of these compositions.

  本发明包括一种由利尿剂或非类固醇抗炎药物、适合制药的载体和降压药组成的药物组合物，以及生产这些组合物的工艺。
• Pharmaceutical compositions comprising angiotensin II receptor blocking imidazoles and diuretics
  申请人：E.I. DU PONT DE NEMOURS AND COMPANY

  公开号：EP0733366A2

  公开（公告）日：1996-09-25

  The invention encompasses a pharmaceutical composition comprising a diuretic or a non-steroidal antiinflammatory drug, a pharmaceutical suitable carrier and an antihypertensive and processes for production of these compositions.

  本发明包括一种由利尿剂或非类固醇抗炎药物、适合制药的载体和降压药组成的药物组合物，以及生产这些组合物的工艺。
• Treatment of central nervous system disorders with imidazole angiotensin-II receptor antagonists
  申请人：E.I. DU PONT DE NEMOURS AND COMPANY

  公开号：EP0803252A2

  公开（公告）日：1997-10-29

  Substituted imidazoles such as 2-butyl-4-chloro-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]-5-(hydroxymethyl)imidazole and 2-butyl-4-chloro-1-[(2'-carboxybiphenyl-4-yl)methyl]-5-(hydroxymethyl)imidazole and pharmaceutically acceptable salts thereof are useful for treating central nervous system disorders, such as cognitive and learning disorders, mediated by angiotensin II.

  取代的咪唑，如 2-丁基-4-氯-1-[(2'-(1H-四唑-5-基)联苯-4-基)甲基]-5-(羟甲基)咪唑和 2-丁基-4-氯-1-[(2'-羧基联苯-4-基)甲基]-5-(羟甲基)咪唑及其药学上可接受的盐类可用于治疗中枢神经系统疾病、如由血管紧张素 II 介导的认知和学习障碍。