Spiro[1H-indene-1,4a(2)-piperidine]-1a(2)-propanol | 481002-03-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚和异茚
• 英文名称: Spiro[1H-indene-1,4a(2)-piperidine]-1a(2)-propanol
• 英文别名: 3-spiro[indene-1,4'-piperidine]-1'-ylpropan-1-ol
• CAS: 481002-03-3
• 化学式: C₁₆H₂₁NO
• 分子量: 243.34
• InChiKey: DXKPUJWJNCXXEU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• SPIROPIPERIDINE COMPOUNDS AS LIGANDS FOR ORL-1 RECEPTOR
  申请人：PFIZER INC.

  公开号：EP1399432A1

  公开（公告）日：2004-03-24
• Spiropoperidine compounds as ligands for orl-1 receptor
  申请人：Ando Koji

  公开号：US20050038060A1

  公开（公告）日：2005-02-17

  A compound of the formula (I) or a salt, prodrug or solvate thereof, wherein R 1 and R 2 groups are all hydrogen; A is a benzofuzed azahetero ring; W 1 —W 2 is CH 2 —CH 2 ; X 1 —X 1 is CH 2 —CH 2 ; and Z is methylene or carbonyl; or the like, is a ligand for ORL1-receptor and are useful for treating or preventing pain, a CNS disorder or the like in mammalian subjects.
• [EN] SPIROPIPERIDINE COMPOUNDS AS LIGANDS FOR ORL-1 RECEPTOR<br/>[FR] COMPOSES DE SPIROPIPERIDINE UTILISES COMME LIGANDS POUR LE RECEPTEUR ORL-1
  申请人：PFIZER PHARMA

  公开号：WO2003000677A1

  公开（公告）日：2003-01-03

  A compound of the formula (I) or a salt, prodrug or solvate thereof, wherein R?1 and R2¿ groups are all hydrogen; A is a benzofuzed azahetero ring; W1-W2 is CH¿2?-CH2; X?1-X1¿ is CH¿2?-CH2; and Z is methylene or carbonyl; or the like, is a ligand for ORL1-receptor and are useful for treating or preventing pain, a CNS disorder or the like in mammalian subjects.