Bamethan hydrochloride | 147418-85-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: Bamethan hydrochloride
• 英文别名: 4-[2-(butylamino)-1-hydroxyethyl]phenol;hydrochloride
• CAS: 147418-85-7
• 化学式: C12H20ClNO2
• 分子量: 245.74
• InChiKey: PDVPUUWBYQMKHW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.24
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  52.5
• 氢给体数：
  4
• 氢受体数：
  3

文献信息

• Synthesis and uses of synephrine derivatives
  申请人：Chen Jian

  公开号：US20050250944A1

  公开（公告）日：2005-11-10

  The present invention discloses a novel syntheses of synephrine, its derivatives, and the salts of the foregoing, including their intermediates. One or more of the substituents of the nitrogen atom of the synephrine is/are modified to produce the derivatives. The synephrine derivatives and their salts are useful for treating animals for diseases, conditions, or disorders modulated by β 3 -adrenergic receptor. They are preferably used as fat breakdown agents and/or weight loss agents.

  本发明公开了一种新型合成橙皮碱、其衍生物和上述衍生物的盐，包括它们的中间体。橙皮碱的氮原子的一个或多个取代基被修改以产生衍生物。橙皮碱衍生物及其盐可用于治疗受β3-肾上腺素受体调节的动物的疾病、症状或紊乱。它们通常用作脂肪分解剂和/或减肥剂。
• [EN] SYNTHESIS AND USES OF SYNEPHRINE DERIVATIVES<br/>[FR] SYNTHESE ET UTILISATIONS DE DERIVES DE SYNEPHRINE
  申请人：SYNTECH SSPF INTERNAT INC

  公开号：WO2005108381A1

  公开（公告）日：2005-11-17

  The present invention discloses a novel syntheses of synephrine, its derivatives, and the salts of the foregoing, including their intermediates. One or more of the substituents of the nitrogen atom of the synephrine is/are modified to produce the derivatives. The synephrine derivatives and their salts are useful for treating animals for diseases, conditions, or disorders modulated by β3-adrenergic receptor. They are preferably used as fat breakdown agents and/or weight loss agents.