| 1065271-85-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• CAS: 1065271-85-3；1065271-86-4
• 化学式: C₃₃H₂₈F₃O₄PS
• 分子量: 608.618
• InChiKey: UMXNAISNUXAQMJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.54
• 重原子数：
  42.0
• 可旋转键数：
  6.0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  60.44
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  在 sodium hydroxide 作用下， 以 1,4-二氧六环 、 甲醇 为溶剂， 反应 18.0h， 生成
  参考文献：
  名称：

  Synthesis and evaluation of P-chirogenic monodentate binaphthyl phosphines

  摘要：

  P-Chirogenic monodentate binaphthyl phosphines were prepared in five steps from enantiomerically pure BINOL This approach supposes the utilization of two methods previously developed in our group, the formation of secondary phosphine oxide, and the reduction of tertiary phosphine oxide using the association of tetramethyldisiloxane and Ti((OPr)-Pr-i)(4). During the last reduction step, only the formation of the more stable diastereoisomer was observed. This product was employed as a ligand for the palladium catalyzed hydrosilylation of styrene to afford the corresponding alcohol with high yield and enantiomeric excess. (C) 2012 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tetlet.2012.07.136
• 作为产物：
  描述：

  cyclohexyl(phenyl)phosphine oxide 、 (R)-trifluoro-methanesulfonic acid 2’-trifluoromethanesulfonyloxy [1,1’]binapthalenyl-2-yl ester 在 palladium diacetate 、 N,N-二异丙基乙胺 、 1,4-双(二苯基膦)丁烷 作用下， 以 二甲基亚砜 为溶剂， 反应 16.0h， 以66%的产率得到
  参考文献：
  名称：

  Synthesis and evaluation of P-chirogenic monodentate binaphthyl phosphines

  摘要：

  P-Chirogenic monodentate binaphthyl phosphines were prepared in five steps from enantiomerically pure BINOL This approach supposes the utilization of two methods previously developed in our group, the formation of secondary phosphine oxide, and the reduction of tertiary phosphine oxide using the association of tetramethyldisiloxane and Ti((OPr)-Pr-i)(4). During the last reduction step, only the formation of the more stable diastereoisomer was observed. This product was employed as a ligand for the palladium catalyzed hydrosilylation of styrene to afford the corresponding alcohol with high yield and enantiomeric excess. (C) 2012 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tetlet.2012.07.136

文献信息

• Synthesis of P-stereogenic BINAP bissulfide analogues
  作者：Eoin Rafter、Jimmy Muldoon、Helge Müller Bunz、Declan G. Gilheany

  DOI：10.1016/j.tetasy.2011.09.007

  日期：2011.9

  A synthetic route to BINAP disulfide analogues with chirality on one of the phosphorus atoms was developed. The synthesis of these ligands was achieved by step-wise palladium and nickel-catalysed coupling reactions of the precursor binaphthyl triflate with secondary phosphines and phosphine oxides, respectively. C2-Unsymmeric BINAP bissulfide analogues with the same aryl substituents were also synthesized for the sake of comparison. Preliminary studies of the reduction of these sulfides to the free phosphines are also described. (C) 2011 Elsevier Ltd. All rights reserved.