2-(2,5-difluoro-benzyl)-1,2,3,4-tetrahydro-isoquinolin-8-ol | 827310-55-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: 2-(2,5-difluoro-benzyl)-1,2,3,4-tetrahydro-isoquinolin-8-ol
• 英文别名: 2-[(2,5-Difluorophenyl)methyl]-1,2,3,4-tetrahydroisoquinolin-8-ol；2-[(2,5-difluorophenyl)methyl]-3,4-dihydro-1H-isoquinolin-8-ol
• CAS: 827310-55-4
• 化学式: C₁₆H₁₅F₂NO
• 分子量: 275.298
• InChiKey: YVRWYILBACZNLR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Azacyclic compounds as inhibitors of sensory neurone specific channels
  申请人：Hamlyn John Richard

  公开号：US20070043024A1

  公开（公告）日：2007-02-22

  Compounds of the formula (I), and pharmaceutically acceptable salts thereof, are found to be antagonists of SNS sodium channels. They are therefore useful as analgesic and neuroprotective agents wherein: X is —N— or —CH—; n is from 0 to 3.

  公式（I）的化合物及其药学上可接受的盐被发现是SNS钠通道的拮抗剂。因此，它们可用作镇痛和神经保护剂，其中：X为—N—或—CH—; n为0至3。
• AZACYCLIC COMPOUNDS AS INHIBITORS OF SENSORY NEURONE SPECIFIC CHANNELS
  申请人：Vernalis (R&D) Limited

  公开号：EP1660454A1

  公开（公告）日：2006-05-31
• A2B ADENOSINE RECEPTOR ANTAGONISTS
  申请人：CV THERAPEUTICS, INC.

  公开号：EP1678181A2

  公开（公告）日：2006-07-12
• [EN] AZACYCLIC COMPOUNDS AS INHIBITORS OF SENSORY NEURONE SPECIFIC CHANNELS<br/>[FR] COMPOSES AZACYCLIQUES CONVENANT COMME INHIBITEURS DES CANAUX SPECIFIQUES DES NEURONES SENSORIELS
  申请人：IONIX PHARMACEUTICALS LTD

  公开号：WO2005005392A1

  公开（公告）日：2005-01-20

  [EN] Compounds of the formula (I), and pharmaceutically acceptable salts thereof, are found to be antagonists of SNS sodium channels. They are therefore useful as analgesic and neuroprotective agents wherein: X is -N- or -CH-; n is from 0 to 3.
  [FR] La présente invention concerne des composés représentés par la formule générale (I) et certains de leurs sels pharmaceutiquement admis. Ces produits, qui s'avèrent des antagonistes des canaux sodium des neurones sensoriels, conviennent donc comme analgésiques et neuroprotecteurs. Dans cette formule, X est -N- ou -CH-, et "n" vaut de 0 à 3.
• [EN] A2B ADENOSINE RECEPTOR ANTAGONISTS<br/>[FR] ANTAGONISTES DU RECEPTEUR DE L'ADENOSINE A2B
  申请人：CV THERAPEUTICS INC

  公开号：WO2005042534A2

  公开（公告）日：2005-05-12

  Disclosed are novel compounds that are A2B adenosine receptor antagonists having the following structure (I) wherein R1 and R2 are independently chosen from hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted aryl, and optionally substituted heteroaryl, and R4 is an optionally substituted heteroaryl moiety. The compounds of the invention are useful for treating various disease states, including asthma, chronic obstructive pulmonary disorder, pulmonary inflammation, emphysema, diabetic disorders, inflammatory gastrointestinal tract disorders, immunological/inflammatory disorders, cardiovascular diseases, neurological disorders, and diseases related to angiogenesis.