1,1-Dimethyl-1,2,3,4-tetrahydronaphthalen-2-amine | 112904-95-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: 1,1-Dimethyl-1,2,3,4-tetrahydronaphthalen-2-amine
• 英文别名: 1,1-dimethyl-3,4-dihydro-2H-naphthalen-2-amine
• CAS: 112904-95-7
• 化学式: C₁₂H₁₇N
• 分子量: 175.27
• InChiKey: MTJBBLASZIKFEM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• Cyanoamidine P2X7 antagonists for the treatment of pain
  申请人：Carroll A. William

  公开号：US20060025614A1

  公开（公告）日：2006-02-02

  Novel cyanoamidines compounds of formula (I) and (II) and their derivatives wherein R 1 -R 12 are as defined in the specification act as antagonists of the P2X 7 receptor. These compounds are particularly useful in the treatment of pain, inflammation and neurodegeneration states.

  新型氰胺基化合物的化学式(I)和(II)及其衍生物，其中R1-R12如规范中定义的作为P2X7受体的拮抗剂。这些化合物在治疗疼痛、炎症和神经退行性状态方面特别有用。
• Cyanoamidine P2X7 Antagonists for the Treatment of Pain
  申请人：Carroll A. William

  公开号：US20070232686A1

  公开（公告）日：2007-10-04

  Novel cyanoamidines compounds of formula (I) and (II) and their derivatives wherein R 1 -R 12 are as defined in the specification act as antagonists of the P2X 7 receptor. These compounds are particularly useful in the treatment of pain, inflammation and neurodegeneration states.

  化合物(I)和(II)以及它们的衍生物，其化学式中R1-R12如规范中定义，可作为P2X7受体的拮抗剂。这些化合物在治疗疼痛、炎症和神经退行性疾病方面特别有用。
• US7241776B2
  申请人：——

  公开号：US7241776B2

  公开（公告）日：2007-07-10
• [EN] CYANOAMIDINE P2X7 ANTAGONISTS FOR THE TREATMENT OF PAIN<br/>[FR] CYANOAMIDINES ANTAGONISTES DE P2X7 POUR LE TRAITEMENT DE LA DOULEUR
  申请人：ABBOTT LAB

  公开号：WO2006017406A1

  公开（公告）日：2006-02-16

  cyanoamidines compounds of formula (I) and (II) and their derivatives wherein R1 - R12 are as defined in the specification act as antagonists of the P2X7 receptor. These compounds are particularly useful in the treatment of pain, inflammation and neurodegeneration states.