Flumethasone 17-valerate | 22194-28-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: Flumethasone 17-valerate
• 英文别名: [(6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] pentanoate
• CAS: 22194-28-1
• 化学式: C₂₇H₃₆F₂O₆
• 分子量: 494.6
• InChiKey: WVSXUIDOQJEBLB-MSIMIBAWSA-N

物化性质

• 沸点：
  600.5±55.0 °C(Predicted)
• 密度：
  1.27±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  35
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.74
• 拓扑面积：
  101
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• Composition for treating the cutaneous atrophy associated with topical steroid use comprising a salt of C3-7 alpha-hydroxy carboxylic acid
  申请人：Bristol-Myers Squibb Company

  公开号：EP0504862A1

  公开（公告）日：1992-09-23

  The cutaneous atrophy associated with the use of steroids topically can be ameliorated using salts of certain α-hydroxyacids.

  使用某些α-羟基酸盐可以改善局部使用类固醇引起的皮肤萎缩。
• Compositions and methods for treating pathological infections
  申请人：Manandhar P. Madhusudan

  公开号：US20060003969A1

  公开（公告）日：2006-01-05

  The present invention relates to compositions and methods for treating pathological infections. An embodiment of the present invention is directed to a topical composition useful for the treatment of yeast, fungal or bacterial infections of a patient in need of such treatment which includes a pharmaceutically effective amount of an anti-yeast, anti-fungal or antibacterial pharmaceutically active agent; and a pharmaceutically acceptable carrier.

  本发明涉及治疗病理感染的组合物和方法。本发明的一个实施方案涉及一种局部组合物，用于治疗需要治疗的患者的酵母、真菌或细菌感染，该组合物包括药学上有效量的抗酵母、抗真菌或抗菌药学活性剂；以及药学上可接受的载体。
• COMPOSITIONS AND METHODS FOR TREATING PATHOLOGICAL INFECTIONS
  申请人：Warner-Lambert Company LLC

  公开号：EP1763341A2

  公开（公告）日：2007-03-21
• TOPICAL COMPOSITIONS COMPRISING CORTICOSTEROIDS
  申请人：CADILA HEALTHCARE LIMITED

  公开号：US20180235882A1

  公开（公告）日：2018-08-23

  The present invention relates to the treatment of psoriasis and other skin disorders. More particularly, the present invention relates to compositions for treating such disorders, the compositions comprising submicron size droplets of corticosteroids and salts or esters thereof with oily excipients. The present invention also relates to process for the preparation of such compositions.
• US4017615A
  申请人：——

  公开号：US4017615A

  公开（公告）日：1977-04-12