6-(dimethylamino)phthalazine-1,4-dione | 71982-97-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 6-(dimethylamino)phthalazine-1,4-dione
• 英文别名: 5-(Dimethylamino)phthalazine-1,4-dione
• CAS: 71982-97-3
• 化学式: C₁₀H₉N₃O₂
• 分子量: 203.2
• InChiKey: OFMPEJHKSRKVLJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  62.1
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Modulation of cell fates and activities by phthalazinediones
  申请人：Henry O. Mark

  公开号：US20070142303A1

  公开（公告）日：2007-06-21

  Phthalazinediones that function as intracellular redox modulators are useful in treating cells in various disease states where intracellular redox status is impaired. By buffering aberrant redox states, phthalazinediones enable cellular processes essential for survival and augment medical treatments. The phthalazinediones of the invention can modulate functions related to cell growth, differentiation, activity, or death, to correct aberrations and restore homeostasis, and can serve as adjunctive therapy in treating various disease conditions.
• MODULATION OF CELL FATES AND ACTIVITIES BY PHTHALAZINEDIONES
  申请人：Henry Mark O.

  公开号：US20140030317A1

  公开（公告）日：2014-01-30

  Phthalazinediones that function as intracellular redox modulators are useful in treating cells in various disease states where intracellular redox status is impaired. By buffering aberrant redox states, phthalazinediones enable cellular processes essential for survival and augment medical treatments. The phthalazinediones of the invention can modulate functions related to cell growth, differentiation, activity, or death, to correct aberrations and restore homeostasis, and can serve as adjunctive therapy in treating various disease conditions.
• US7326690B2
  申请人：——

  公开号：US7326690B2

  公开（公告）日：2008-02-05
• US9968602B2
  申请人：——

  公开号：US9968602B2

  公开（公告）日：2018-05-15
• [EN] ENZYMATICALLY ACTIVATABLE PEPTIDE-REDOX MODULATOR CONJUGATES AND USE THEREOF<br/>[FR] CONJUGUÉS PEPTIDE-MODULATEUR REDOX ACTIVABLES PAR VOIE ENZYMATIQUE ET LEUR UTILISATION
  申请人：UNIV BRANDEIS

  公开号：WO2018129171A1

  公开（公告）日：2018-07-12

  Disclosed are peptides capable of enzymatically-induced self-assembly to which is conjugated a redox modulator. These peptides are enzymatically responsive hydrogelators, and they can be used to form pericellular hydrogels/nanofibrils upon exposure to target cells that secrete or express a surface bound ectoenzyme having hydrolase activity suitable to induce peptide gelation. These materials, and compositions containing the same, can be used for inhibiting cancer cell migration, inhibiting cancer cell survival, and/or inhibiting cancer cell growth.