4-(5-benzo[b]thiophen-2-ylpyrimidin-2-yl)-1,4-diazabicyclo[3.2.2]nonane | 1122043-78-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻吩类
• 英文名称: 4-(5-benzo[b]thiophen-2-ylpyrimidin-2-yl)-1,4-diazabicyclo[3.2.2]nonane
• 英文别名: 4-[5-(1-Benzothiophen-2-yl)pyrimidin-2-yl]-1,4-diazabicyclo[3.2.2]nonane
• CAS: 1122043-78-0
• 化学式: C₁₉H₂₀N₄S
• 分子量: 336.461
• InChiKey: WOBBDBJEMCUDEC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  60.5
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• [EN] 1,4-DIAZA-BICYCL0(3.2.2)N0NYL PYRIMIDINYL DERIVATIVES USEFUL AS NICOTINIC ACETYLCHOLINE- RECEPTOR LIGANDS<br/>[FR] DÉRIVÉS DE 1,4-DIAZA-BICYCLO[3.2.2]NONYL PYRIMIDINYLE UTILES EN TANT QUE LIGANDS DES RÉCEPTEURS NICOTINIQUES DE L'ACÉTYLCHOLINE
  申请人：NEUROSEARCH AS

  公开号：WO2009024515A1

  公开（公告）日：2009-02-26

  This invention relates to novel 1,4-diaza-bicyclo[3.2.2]nonyl pyrimidinyl derivatives and their use in the manufacture of pharmaceutical compositions. The compounds of the invention are found to be cholinergic ligands at the nicotinic acetylcholine receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

  该发明涉及新颖的1,4-二氮杂-双环[3.2.2]辛基嘧啶衍生物及其在制备药物组合物中的应用。该发明的化合物被发现是胆碱能受体的胆碱能配体。由于它们的药理特性，该发明的化合物可能对治疗与中枢神经系统（CNS）的胆碱能系统、周围神经系统（PNS）、平滑肌收缩相关的疾病或紊乱、内分泌疾病或紊乱、神经退行性疾病或紊乱、炎症相关的疾病或紊乱、疼痛以及由于滥用化学物质终止而引起的戒断症状可能有用。
• 1,4-DIAZA-BICYCLO[3.2.2]NONYL PYRIMIDINYL DERIVATIVES USEFUL AS NICOTINIC ACETYLCHOLINE-RECEPTOR LIGANDS
  申请人：Peters Dan

  公开号：US20100286128A1

  公开（公告）日：2010-11-11

  This invention relates to novel 1,4-diaza-bicyclo[3.2.2]nonyl pyrimidinyl derivatives and their use in the manufacture of pharmaceutical compositions. The compounds of the invention are found to be cholinergic ligands at the nicotinic acetylcholine receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

  本发明涉及新型1,4-二氮杂双环[3.2.2]壬基嘧啶衍生物及其在制造药物组合物中的应用。该发明的化合物被发现是尼古丁酸乙酰胆碱受体的胆碱能配体。由于其药理学特性，该发明的化合物可能对与中枢神经系统（CNS）和外周神经系统（PNS）的胆碱能系统相关的疾病或疾病有用，与平滑肌收缩有关的疾病或疾病，内分泌疾病或疾病，神经退行性疾病或疾病，与炎症有关的疾病或疾病，疼痛以及由于滥用化学物质的终止而引起的戒断症状。
• 1,4-DIAZA-BICYCL0(3.2.2)N0NYL PYRIMIDINYL DERIVATIVES USEFUL AS NICOTINIC ACETYLCHOLINE- RECEPTOR LIGANDS
  申请人：NeuroSearch A/S

  公开号：EP2190846A1

  公开（公告）日：2010-06-02