3',5'-dibromo-2'-hydroxyacetophenone imine | 92832-04-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 3',5'-dibromo-2'-hydroxyacetophenone imine
• 英文别名: 2,4-Dibromo-6-ethanimidoylphenol
• CAS: 92832-04-7
• 化学式: C₈H₇Br₂NO
• 分子量: 292.958
• InChiKey: DXQWMSOQXXPBPV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  44.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3',5'-二溴-2'-羟基苯乙酮 在 氨 作用下， 以 甲醇 为溶剂， 反应 24.0h， 以90%的产率得到3',5'-dibromo-2'-hydroxyacetophenone imine
  参考文献：
  名称：

  A simple and convenient synthesis of 4-methyl-3-nitro-2-trihalomethyl-2H-chromenes from N-unsubstituted imines of 2-hydroxyacetophenones and trichloro(trifluoro)ethylidene nitromethanes

  摘要：

  The reaction of N-unsubstituted imines of 2-hydroxyacetophenones with trichloro(trifluoro)ethylidene nitromethanes in the presence of DABCO proceeds via tandem oxa-Michael/aza-Henry additions (in dichloromethane) or aza-Michael addition (in benzene) to give 4-methyl-3-nitro-2-trichloro(trifluoro)-methyl-2H-chromenes or 1,1,1-trichloro(trifluoro)-3-nitro-N-[1-(2-hydroxyaryl)ethylidene]propan-2-amines, respectively. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.03.065

文献信息

• NOVEL SUBSTITUTED BICYCLIC COMPOUNDS AS BROMODOMAIN INHIBITORS
  申请人：ZENITH EPIGENETICS CORP.

  公开号：US20160184273A1

  公开（公告）日：2016-06-30

  The invention relates to substituted bicyclic compounds, which are useful for inhibition of BET protein function by binding to bromodomains, pharmaceutical compositions comprising these compounds, and use of the compounds and compositions in therapy.
• US9662311B2
  申请人：——

  公开号：US9662311B2

  公开（公告）日：2017-05-30