2-Chloro-4-(3,3,3-trifluoropropyl)phenol | 653578-50-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 2-Chloro-4-(3,3,3-trifluoropropyl)phenol
• CAS: 653578-50-8
• 化学式: C₉H₈ClF₃O
• 分子量: 224.61
• InChiKey: IMHGGYINYXFQDY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Ppar alpha selective compounds for the treatment of dyslipidemia and other lipid disorders
  申请人：Shi Q. Guo

  公开号：US20050228044A1

  公开（公告）日：2005-10-13

  A class of benzodihydrofuran compounds having the structure of formula (I) below and pharmaceutically acceptable salts thereof are useful as therapeutic compounds, particularly in the treatment of hyperlipidemia, hypercholesterolemia, dyslipidemia, and other lipid disorders, and in delaying the onset of or reducing the risk of conditions and sequelae that are associated with these diseases, such as atherosclerosis.

  一类苯并二氢呋喃化合物，其结构式为（I），以及其药学上可接受的盐，可用作治疗化合物，特别是用于治疗高脂血症、高胆固醇血症、脂质代谢异常和其他脂质紊乱，并延缓或降低与这些疾病相关的病症和后遗症的发生风险，如动脉粥样硬化。
• PPAR ALPHA SELECTIVE COMPOUNDS FOR THE TREATMENT OF DYSLIPIDEMIA AND OTHER LIPID DISORDERS
  申请人：Merck & Co., Inc.

  公开号：EP1539136A2

  公开（公告）日：2005-06-15
• EP1539136A4
  申请人：——

  公开号：EP1539136A4

  公开（公告）日：2006-10-18
• US7524882B2
  申请人：——

  公开号：US7524882B2

  公开（公告）日：2009-04-28
• [EN] PPAR ALPHA SELECTIVE COMPOUNDS FOR THE TREATMENT OF DYSLIPIDEMIA AND OTHER LIPID DISORDERS<br/>[FR] COMPOSES SELECTIFS DES RECEPTEURS PPAR ALPHA DESTINES AU TRAITEMENT DE LA DYSLIPIDEMIE ET D'AUTRES TROUBLES LIPIDIQUES
  申请人：MERCK & CO INC

  公开号：WO2004010936A2

  公开（公告）日：2004-02-05

  A class of benzodihydrofuran compounds having the structure of formula (I) below and pharmaceutically acceptable salts thereof are useful as therapeutic compounds, particularly in the treatment of hyperlipidemia, hypercholesterolemia, dyslipidemia, and other lipid disorders, and in delaying the onset of or reducing the risk of conditions and sequelae that are associated with these diseases, such as atherosclerosis.