4-[(2-Chloroethyl)amino]phenol | 49577-86-8

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 4-[(2-Chloroethyl)amino]phenol
• 英文别名: 4-(2-chloroethylamino)phenol
• CAS: 49577-86-8
• 化学式: C₈H₁₀ClNO
• 分子量: 171.62
• InChiKey: DATJHFMEARFPDT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  32.3
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• CHLOROTOXINS AS DRUG CARRIERS
  申请人：Transmolecular, Inc.

  公开号：EP2173385A1

  公开（公告）日：2010-04-14
• US6303569B1
  申请人：——

  公开号：US6303569B1

  公开（公告）日：2001-10-16
• [EN] CHLOROTOXINS AS DRUG CARRIERS<br/>[FR] CHLOROTOXINES EN TANT QUE VÉHICULES DE MÉDICAMENT
  申请人：TRANSMOLECULAR INC

  公开号：WO2009021136A1

  公开（公告）日：2009-02-12

  The present invention relates to the use of a toxin moiety (e.g., a chlorotoxin moiety) as a carrier for therapeutic agents, e.g., therapeutic agents that require intracellular uptake to exert their effects. For example, in some embodiments, the present invention provides conjugates comprising a toxin (e.g., a chlorotoxin) moiety and an anti-cancer moiety and methods for using such conjugates to increase cellular uptake and/or increase specificity for cancer cells of the anti-cancer drug. In some embodiments, the present invention provides conjugates comprising a toxin moiety (e.g., a chlorotoxin moiety) and a nucleic acid agent. Also provided are methods of treatment involving administration of such conjugates, and pharmaceutical compositions and kits useful for carrying out such methods of treatment.