25,27-Dihydroxycholestan-26-oic acid | 70021-49-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 25,27-Dihydroxycholestan-26-oic acid
• 英文别名: (6R)-6-[(8R,9S,10S,13R,14S,17R)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-hydroxy-2-(hydroxymethyl)heptanoic acid
• CAS: 70021-49-7
• 化学式: C₂₇H₄₆O₄
• 分子量: 434.7
• InChiKey: LIBMVGAVFUIWNV-CZAZNYCHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.5
• 重原子数：
  31
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.96
• 拓扑面积：
  77.8
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• METHODS FOR THE DETECTION OF PREECLAMPSIA
  申请人：The University Of Western Ontario

  公开号：EP2147309A1

  公开（公告）日：2010-01-27
• METHODS AND COMPOSITIONS FOR DIAGNOSING, PROGNOSING, AND CONFIRMING PREECLAMPSIA
  申请人：Cooper, Matthew

  公开号：EP3175239A1

  公开（公告）日：2017-06-07
• COMPOSITIONS AND METHODS FOR TREATMENT OF PEROXISOMAL DISORDERS AND LEUKODYSTROPHIES
  申请人：The Johns Hopkins University

  公开号：EP3368088A1

  公开（公告）日：2018-09-05
• METHODS FOR DETECTION OF PREECLAMPSIA
  申请人：Lajoie Gilles Andre

  公开号：US20100113286A1

  公开（公告）日：2010-05-06

  Biomarkers associated with preeclampsia were identified. Nine proteins were identified as being differentially regulated between the control and the under 28-weeks preeclamptic samples. Similarly three proteins were identified as being differentially regulated between the control and the over 28-weeks preeclamptic samples. These 12 proteins can be used as potential biomarkers in the diagnosing and prognosing of preeclampsia.
• A SCREENING METHOD FOR CEREBROTENDINOUS XANTHOMATOSIS USING BILE ALCOHOL GLUCURONIDES AND METABOLITE RATIOS
  申请人：Academisch Medisch Centrum

  公开号：US20210033626A1

  公开（公告）日：2021-02-04

  The invention relates to a method of diagnosing or screening for 27-hydroxylase (CYP27A1) deficiency in an animal comprising: determining in a biological sample the intensity signal by mass analysis of at least a bile alcohol glucuronide and a C24- or C27-bile acid or a conjugate thereof, comparing the intensity signals to a control sample or control value, and determining 27-hydroxylase (CYP27A1) deficiency based on said comparison.