2-{2-{[2-(4-tert-Butylthiazol-2-yl)benzofuran-5-yloxy]methyl}phenoxy}-2-methylpropionamide oxime | 194490-05-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶唑类
• 英文名称: 2-{2-{[2-(4-tert-Butylthiazol-2-yl)benzofuran-5-yloxy]methyl}phenoxy}-2-methylpropionamide oxime
• 英文别名: 2-[2-[[2-(4-tert-butyl-1,3-thiazol-2-yl)-1-benzofuran-5-yl]oxymethyl]phenoxy]-N'-hydroxy-2-methylpropanimidamide
• CAS: 194490-05-6
• 化学式: C₂₆H₂₉N₃O₄S
• 分子量: 479.6
• InChiKey: FTKOFXQXIDHPIK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  34
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  131
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• Thiazolybenzofuran derivatives and their use as SRS-A and leukotiene antagonists
  申请人：FUJISAWA PHARMACEUTICAL CO., LTD.

  公开号：EP1170009A2

  公开（公告）日：2002-01-09

  This invention relates to novel thiazolylbenzofuran derivatives of formula (I) wherein R1 is lower alkyl, L is single bond or lower alkylene optionally substituted with aryl, oxo or hydroxy, and Q is a heterocyclix group optionally substituted with one or more suitable substituent(s); or lower alkoxy substituted with aryl which is substituted with one or more suitable substituent(s) and at least one of which is lower alkoxy optionally substituted with cyano, protected carboxy, carboxy, lower alkylene, a heterocyclic group optionally substituted with oxo, or amidino optionally substituted with hydroxy or lower alkoxy, or its salt, which possess activities as leukotriene and SRS-A antagonists or inhibitors.

  本发明涉及式（I）的新型噻唑基苯并呋喃衍生物，其中 R1 是低级烷基，L 是单键或可选被芳基、氧代或羟基取代的低级亚烷基，Q 是可选被一个或多个合适取代基取代的杂环基团；或被芳基取代的低级烷氧基，该芳基被一个或多个合适的取代基取代，且其中至少一个低级烷氧基被氰基、受保护的羧基、羧基、低级亚烷基、可选被氧代取代的杂环基团或可选被羟基或低级烷氧基取代的脒基取代，或其盐，具有作为白三烯和 SRS-A 拮抗剂或抑制剂的活性。
• THIAZOLYLBENZOFURAN DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
  申请人：FUJISAWA PHARMACEUTICAL CO., LTD.

  公开号：EP0880519A1

  公开（公告）日：1998-12-02
• US5994378A
  申请人：——

  公开号：US5994378A

  公开（公告）日：1999-11-30
• [EN] THIAZOLYLBENZOFURAN DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM<br/>[FR] DERIVES DU THIAZOLYLBENZOFURANNE ET COMPOSITIONS PHARMACEUTIQUES LES CONTENANT
  申请人：FUJISAWA PHARMACEUTICAL CO., LTD.

  公开号：WO1997027190A1

  公开（公告）日：1997-07-31

  (EN) This invention relates to novel thiazolylbenzofuran derivatives of formula (I) wherein R1 is lower alkyl, L is single bond or lower alkylene optionally substituted with aryl, oxo or hydroxy, and Q is a heterocyclic group optionally substituted with one or more suitable substituent(s); or lower alkoxy substituted with aryl which is substituted with one or more suitable substituent(s) and at least one of which is lower alkoxy optionally substituted with cyano, protected carboxy, carboxy, lower alkylene, a heterocyclic group optionally substituted with oxo, or amidino optionally substituted with hydroxy or lower alkoxy, or its salt, which possess activities as leukotriene and SRS-A antagonists or inhibitors.(FR) L'invention concerne de nouveaux dérivés du thiazolylbenzofuranne de formule (I), où R1 est alkyle inférieur; L est une simple liaison ou un alkylène inférieur éventuellement substitué par aryle, oxo ou hydroxy; et Q est un groupe hétérocyclique éventuellement substitué par un ou plusieurs substituants appropriés; ou alcoxy inférieur substitué par un aryle, qui est substitué par un ou plusieurs substituants appropriés et dont au moins un est un alcoxy inférieur substitué par cyano, carboxy protégé, carboxy, alkylène inférieur, un groupe hétérocyclique éventuellement substitué par oxo, ou amidino éventuellement substitué par hydroxy ou alcoxy inférieur, ou un sel de ces dérivés, qui sont actifs comme antagonistes ou inhibiteurs de la substance SRS-A ou des leucotriènes.