| 1196204-53-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 萘并噻唑类
• CAS: 1196204-53-1
• 化学式: C₁₅H₁₉N₂O₃PS
• 分子量: 338.367
• InChiKey: RVRLSTHGFPAPEP-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  在 三甲基溴硅烷 作用下， 以 二氯甲烷 为溶剂， 生成 2-Amino-4,5-dihydronaphtho[1,2-d]thiazol-8-ylphosphonic acid
  参考文献：
  名称：

  Synthesis, SAR, and X-ray structure of tricyclic compounds as potent FBPase inhibitors

  摘要：

  With the aim of discovering a novel class of fructose-1,6-bisphosphatase (FBPase) inhibitors, a series of compounds based on tricyclic scaffolds was synthesized. Extensive SAR studies led to the finding of 8l with an IC50 value of 0.013 mu M against human FBPase. An X-ray crystallographic study revealed that 8l bound at AMP binding sites of human liver FBPase with hydrogen bonding interactions similar to AMP. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.08.081
• 作为产物：
  描述：

  、 硫脲 在 sodium acetate 作用下， 以 乙醇 为溶剂， 生成
  参考文献：
  名称：

  Synthesis, SAR, and X-ray structure of tricyclic compounds as potent FBPase inhibitors

  摘要：

  With the aim of discovering a novel class of fructose-1,6-bisphosphatase (FBPase) inhibitors, a series of compounds based on tricyclic scaffolds was synthesized. Extensive SAR studies led to the finding of 8l with an IC50 value of 0.013 mu M against human FBPase. An X-ray crystallographic study revealed that 8l bound at AMP binding sites of human liver FBPase with hydrogen bonding interactions similar to AMP. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.08.081