2-Hydroxynaphthalen-1(2H)-one | 77488-21-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-Hydroxynaphthalen-1(2H)-one
• 英文别名: 2-hydroxy-2H-naphthalen-1-one
• CAS: 77488-21-2
• 化学式: C₁₀H₈O₂
• 分子量: 160.17
• InChiKey: GEYCYCTZOOCRJL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Process for producing 6-hydroxy-2-naphthones
  申请人：CELANESE CORPORATION

  公开号：EP0264168A2

  公开（公告）日：1988-04-20

  A process is provided for the production of 6-hydroxy-2-naphthones, e.g., 6-hydroxy-2-acetonaphthone, by contacting a 2-naphthyl carboxylate ester, e.g., 2-naphthyl acetate with at least 20 moles of hydrogen fluoride per mole of 2-naphthyl ester, at reaction temperatures, e.g., 0 to 100° C for a period of reaction, e.g., 30 minutes to 8 hours sufficient to produce the desired amount of 6-hydroxy-2-naphthone. The process may utilize a carboxylic acid or anhydride, e.g., acetic acid or anhydride as an additive for the purpose of further increasing the regioselectivity of the 6-hydroxy-2-naphthone product. The process is capable of being carried out at a conversion of 2-naphthyl ester of at least 90% and a regioselectivity to 6-hydroxy-2-naphthone of at least 90 mol %.

  本发明提供了一种生产 6-羟基-2-萘酮（如 6-羟基-2-乙酰萘酮）的工艺，其方法是将 2-萘基羧酸酯（如 2-萘基乙酸酯）与每摩尔 2-萘基酯至少 20 摩尔的氟化氢接触，在反应温度（如 0 至 100 摄氏度）下反应一段时间（如 0 至 100 摄氏度）、2-萘乙酸酯与每摩尔 2-萘酯至少 20 摩尔的氟化氢接触，反应温度如 0 至 100 摄氏度，反应时间如 30 分钟至 8 小时，足以生成所需数量的 6-羟基-2-萘酮。为了进一步提高 6-羟基-2-萘酮产物的区域选择性，该工艺可使用羧酸或酸酐，如乙酸或酸酐作为添加剂。该工艺的 2-萘酯转化率至少为 90%，6-羟基-2-萘酮的区域选择性至少为 90 摩尔%。
• Selective activators of the intermediate conductance CA2+activated K+ channel KCa3.1 and their methods of use
  申请人：The Regents of the University of California

  公开号：US11173146B2

  公开（公告）日：2021-11-16

  Benzoxazole and indole type KCa3.1 activators as well as the therapeutic uses of such compounds in human or animal subjects and their use in ex vivo preservation of organs or tissues.

  苯并噁唑和吲哚类 KCa3.1 激活剂，以及此类化合物在人类或动物身上的治疗用途及其在器官或组织体外保存中的用途。
• BICYCLIC CARBOXYLIC ACID LEUKOTRIENE B 4? ANTAGONISTS
  申请人：F. HOFFMANN-LA ROCHE AG

  公开号：EP0682662A1

  公开（公告）日：1995-11-22
• BICYCLIC CARBOXYLIC ACID LEUKOTRIENE B4 ANTAGONISTS
  申请人：F. HOFFMANN-LA ROCHE AG

  公开号：EP0682662B1

  公开（公告）日：1999-08-18
• SELECTIVE ACTIVATORS OF THE INTERMEDIATE CONDUCTANCE CA2+ACTIVATED K+ CHANNEL KCa3.1 AND THEIR METHODS OF USE
  申请人：The Regents of the University of California

  公开号：US20170056376A1

  公开（公告）日：2017-03-02

  Benzoxazole and indole type KCa3.1 activators as well as the therapeutic uses of such compounds in human or animal subjects and their use in ex vivo preservation of organs or tissues.