5-chloro-N-((1R,3S)-3-((3,5-difluoro-6-(5-fluoro-1H-pyrazolo[3,4-b]pyridin-3-yl)pyridin-2-yl)amino)cyclohexyl)thiophene-3-carboxamide | 1383485-86-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡唑并吡啶类
• 英文名称: 5-chloro-N-((1R,3S)-3-((3,5-difluoro-6-(5-fluoro-1H-pyrazolo[3,4-b]pyridin-3-yl)pyridin-2-yl)amino)cyclohexyl)thiophene-3-carboxamide
• 英文别名: 5-chloro-N-[(1R,3S)-3-[[3,5-difluoro-6-(5-fluoro-2H-pyrazolo[3,4-b]pyridin-3-yl)pyridin-2-yl]amino]cyclohexyl]thiophene-3-carboxamide
• CAS: 1383485-86-6
• 化学式: C₂₂H₁₈ClF₃N₆OS
• 分子量: 506.939
• InChiKey: DESBHGDISYKQIV-QWHCGFSZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  34
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  124
• 氢给体数：
  3
• 氢受体数：
  9

文献信息

• INHIBITORS OF INFLUENZA VIRUSES REPLICATION
  申请人：Vertex Pharmaceuticals Incorporated

  公开号：US20140005197A1

  公开（公告）日：2014-01-02

  Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (I) are as described herein. A compound is represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (I) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle.

  抑制生物样本或患者中流感病毒复制、减少生物样本或患者中流感病毒数量、以及治疗患者流感的方法，包括向所述生物样本或患者中投与一种由结构式（I）表示的化合物的有效量或其药学上可接受的盐，其中结构式（I）的值如此处所述。所述化合物由结构式（I）或其药学上可接受的盐表示，其中结构式（I）的值如此处所述。药物组合物包括有效量的该化合物或其药学上可接受的盐，以及药学上可接受的载体、佐剂或载体。