2,2'-(trimethylene)bis[6-chloro-1H-benz[de]isoquinoline-1,3(2H)-dione] | 138002-40-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: 2,2'-(trimethylene)bis[6-chloro-1H-benz[de]isoquinoline-1,3(2H)-dione]
• 英文别名: 2,2'-(Trimethylene)bis[6-chloro-1h-benz[de]-isoquinoline-1,3(2h)-dione]；6-chloro-2-[3-(6-chloro-1,3-dioxobenzo[de]isoquinolin-2-yl)propyl]benzo[de]isoquinoline-1,3-dione
• CAS: 138002-40-1
• 化学式: C₂₇H₁₆Cl₂N₂O₄
• 分子量: 503.341
• InChiKey: MPEAPDUXNMZJHX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  35
• 可旋转键数：
  4
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  74.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4-氯萘二甲酰亚胺 、 1,3-二溴丙烷 在 氢氧化钾 、 butyltetraalkylammonium bromide 、 水 作用下， 以 苯 为溶剂， 反应 4.0h， 以24%的产率得到2,2'-(trimethylene)bis[6-chloro-1H-benz[de]isoquinoline-1,3(2H)-dione]
  参考文献：
  名称：

  Synthesis of 4-Substituted Bisnaphthalimides

  摘要：

  The synthetic route to 4-substituted bisnaphthalimides consisting in reaction of 4-halonaphthalic anhydrides with alpha,omega-diaminoalkanes followed by halogen substitution with dialkylamino group is more promising than imidating coupling of 4-dialkylaminonaphthalic anhydrides for it opens wider synthetic opportunities and ensures better yields of target products. Dihalosubstituted bis-naphthalimides can be prepared by N-alkylation of the corresponding naphthalimides with polymethylene dibromides under conditions of phase-transfer catalysis in the presence of tetraalkylammonium salts.

  DOI：

  10.1023/b:rujo.0000043717.08167.c6

文献信息

• Tetraalkylammonium salts of naphthimide and its halo and nitro derivatives
  作者：V. F. Anikin、N. F. Fed’ko

  DOI：10.1134/s1070427206030153

  日期：2006.3

  Synthesis of tetraalkylammonium salts of naphthimide and its derivatives was studied.
• Electron impact mass spectrometry of some unsubstituted and chlorine-substituted bisnaphthalimides and related synthons
  作者：L. Krotz、R. Seraglia、P. Traldi、F. Guidugli、J. Kavka、C. Gaozza

  DOI：10.1002/oms.1210261011

  日期：1991.10

  AbstractThe electron impact induced fragmentations of some unsubstituted and chlorine‐substituted naphthalimides and bisnaphthalimides are discussed in detail with the aid of B/E and B2/E linked‐scans for metastable ion analysis and collisional activation experiments. In the case of bisnaphthalimides the more important primary decomposition routes are related to cleavages of the alkyl chain.