4-oxo-1-phenyl-1,4-dihydro-cinnoline-3-carbonitrile | 55052-91-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 4-oxo-1-phenyl-1,4-dihydro-cinnoline-3-carbonitrile
• 英文别名: 4-Oxo-1-phenylcinnoline-3-carbonitrile
• CAS: 55052-91-0
• 化学式: C₁₅H₉N₃O
• 分子量: 247.256
• InChiKey: JRCAZNDPUKLROO-UHFFFAOYSA-N

物化性质

• 沸点：
  424.7±28.0 °C(Predicted)
• 密度：
  1.24±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  56.5
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Specific nad(p)h oxidase inhibitor
  申请人：Yamamoto Toshihiro

  公开号：US20070082910A1

  公开（公告）日：2007-04-12

  The present invention provides an agent for inhibiting an excessive effect of NAD(P)H oxidase, which contains a compound that does not substantially inhibit the effect of leukocyte NADPH oxidase but inhibits the effect of NAD(P)H oxidase in tissues other than leukocytes, and a pharmaceutical composition containing said inhibitor.