6-(6-amino-hexylamino)-2,3-dihydro-phthalazine-1,4-dione | 66612-31-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 6-(6-amino-hexylamino)-2,3-dihydro-phthalazine-1,4-dione
• 英文别名: 6-[(6-Aminohexyl)amino]-2,3-dihydro-1,4-phthalazinedione；6-(6-aminohexylamino)-2,3-dihydrophthalazine-1,4-dione
• CAS: 66612-31-5
• 化学式: C₁₄H₂₀N₄O₂
• 分子量: 276.338
• InChiKey: ODPPPISXTZZKQL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  20
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  96.2
• 氢给体数：
  4
• 氢受体数：
  4

文献信息

• Control marker for implementing analysis methods on spots
  申请人：BIO-RAD EUROPE GMBH

  公开号：US10139404B2

  公开（公告）日：2018-11-27

  The present invention relates to the use of a control marker for implementing analysis methods on spots, in particular in the context of multiplex analyses. The present invention thus relates to solid supports containing said control marker, their preparation method and their use in analysis methods. The present invention makes it possible to verify the presence, location and/or integrity of the spots at the end of the analysis method, and thus to secure the obtained results while guaranteeing that the yielded result indeed results from a present, intact and localized spot.

  本发明涉及使用对照标记物在斑点上实施分析方法，特别是在多重分析中。因此，本发明涉及含有所述控制标记的固体支持物、其制备方法及其在分析方法中的使用。本发明可以在分析方法结束时验证斑点的存在、位置和/或完整性，从而确保所获得的结果，同时保证所产生的结果确实来自于一个存在的、完整的和定位的斑点。
• Use of a colorant in order to improve signal detection in an analysis method
  申请人：BIO-RAD EUROPE GMBH

  公开号：US10564156B2

  公开（公告）日：2020-02-18

  The use of at least one colorant is provided in order to improve the detection of a signal corresponding to the presence of an analyte in a dot analysis method, in particular when the detection of the signal takes place in the presence of a liquid phase. Also provided is a dot analysis method that can be used to improve the detection of a signal corresponding to the presence of an analyte, in the presence of a liquid phase containing at least one colorant.

  本发明提供了至少一种着色剂的使用方法，以改进点分析方法中与分析物的存在相对应的信号的检测，特别是当信号的检测是在液相存在的情况下进行时。本发明还提供了一种点分析方法，该方法可用于在含有至少一种着色剂的液相存在的情况下，改进与被分析物的存在相对应的信号的检测。
• Compositions, systems, and methods for detecting the presence of polymer subunits using chemiluminescence
  申请人：ILLUMINA, INC.

  公开号：US10633694B2

  公开（公告）日：2020-04-28

  Under one aspect, a composition includes a substrate; a first polynucleotide coupled to the substrate; a second polynucleotide hybridized to the first polynucleotide; and a catalyst coupled to a first nucleotide of the second polynucleotide, the catalyst being operable to cause a chemiluminogenic molecule to emit a photon. Under another aspect, a method includes providing a catalyst operable to cause a first chemiluminogenic molecule to emit a photon; providing a substrate; providing a first polynucleotide coupled to the substrate; hybridizing a second polynucleotide to the first polynucleotide; coupling a first quencher to a first nucleotide of the second polynucleotide; and inhibiting, by the first quencher, photon emission by the first chemiluminogenic molecule.

  根据一个方面，一种组合物包括基底；与基底耦合的第一多核苷酸；与第一多核苷酸杂交的第二多核苷酸；以及与第二多核苷酸的第一核苷酸耦合的催化剂，催化剂可使化学发光分子发射光子。在另一方面，一种方法包括提供一种催化剂，该催化剂可使第一化学发光分子发射光子；提供一种基质；提供与基质耦合的第一多核苷酸；将第二多核苷酸与第一多核苷酸杂交；将第一淬灭剂与第二多核苷酸的第一核苷酸耦合；以及通过第一淬灭剂抑制第一化学发光分子发射光子。
• Controls for implementing multiplex analysis methods
  申请人：BIO-RAD EUROPE GMBH

  公开号：US11226331B2

  公开（公告）日：2022-01-18

  The present invention relates to controls which may be used to secure the results of multiplex analysis methods. The present invention thus relates to solid supports comprising one or several controls and their use in multiplex analysis methods to detect several analytes potentially present in a sample.

  本发明涉及可用于确保多重分析方法结果的对照物。因此，本发明涉及包含一个或多个对照物的固体支持物及其在多重分析方法中的应用，以检测样品中可能存在的多个分析物。
• Antibodies, assay method by using them and judgment method for pancreas cancer
  申请人：Hamada Takatoshi

  公开号：US20060073526A1

  公开（公告）日：2006-04-06

  An antibody which specifically binds to carboxypeptidase A1 (CPA1) and procarboxypeptidase A1 (PCPA1), an antibody which specifically binds to carboxypeptidase A2 (CPA2) and procarboxypeptidase A2 (PCPA2), an antibody which specifically binds to PCPA1, and an antibody which specifically binds to PCPA2, and a hybridoma which produces a monoclonal antibody thereof, are provided. The present invention relates to an antibody which specifically binds to CPA1 and PCPA1, an antibody which specifically binds to CPA2 and PCPA2, an antibody which specifically binds to PCPA1 and an antibody which specifically binds to PCPA2, and a hybridoma which produces a monoclonal antibody thereof; a method for immunologically assaying one or more amount selected from an amount of CPA1, an amount of CPA2, an amount of PCPA1, an amount of PCPA2, and a total amount of two or more amounts selected therefrom (an amount of an object to be assayed); a judging method for pancreas cancer; and a kit therefore. According to the present invention, amounts of the above-described objects to be assayed can be more simply, more quickly and more specifically assayed than in a conventional method. And based on the results assayed, it is possible to judge pancreas cancer or not, especially pancreas cancer at an early stage (stages 1, 2, and the like) or not.

  本发明提供了一种能特异性结合羧肽酶 A1（CPA1）和原羧肽酶 A1（PCPA1）的抗体、一种能特异性结合羧肽酶 A2（CPA2）和原羧肽酶 A2（PCPA2）的抗体、一种能特异性结合 PCPA1 的抗体和一种能特异性结合 PCPA2 的抗体，以及一种能产生其单克隆抗体的杂交瘤。本发明涉及一种特异性结合 CPA1 和 PCPA1 的抗体、一种特异性结合 CPA2 和 PCPA2 的抗体、一种特异性结合 PCPA1 的抗体和一种特异性结合 PCPA2 的抗体，以及一种产生其单克隆抗体的杂交瘤；一种对选自 CPA1 的量、CPA2 的量、PCPA1 的量、PCPA2 的量以及从中选出的两种或两种以上量的总量（待测定对象的量）中的一种或多种量进行免疫测定的方法；一种胰腺癌的判断方法；以及一种试剂盒。根据本发明，与传统方法相比，可以更简单、更快速、更具体地测定上述待测对象的量。根据检测结果，可以判断胰腺癌与否，尤其是早期（1 期、2 期等）胰腺癌与否。