2-(2,3-Dihydro-2-oxo-5H-imadazo[4,5-f]benzoxazol-6-yl sulphinylmethyl)-N,N-dimethyl benzenamine | 113805-20-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2-(2,3-Dihydro-2-oxo-5H-imadazo[4,5-f]benzoxazol-6-yl sulphinylmethyl)-N,N-dimethyl benzenamine
• 英文别名: 6-[[2-(Dimethylamino)phenyl]methylsulfinyl]-3,5-dihydroimidazo[4,5-f][1,3]benzoxazol-2-one
• CAS: 113805-20-2
• 化学式: C₁₇H₁₆N₄O₃S
• 分子量: 356.405
• InChiKey: XZXZXGYUICYWNP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  107
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• Benzimidazoles, their production, formulation and use as gastric acid secretion inhibitors
  申请人：FISONS plc

  公开号：EP0251536A1

  公开（公告）日：1988-01-07

  There are described compounds of formula I,     in which R₁ to R₈ have a variety of significances, including alkoxy, hydrogen, alkyl,     n is 0 or l,     R₁₁ is hydrogen, phenyl, alkenyl, or alkyl optionally substituted by phenyl,     R₉ and R₁₀ have a variety of significances, including cycloalkyl, alkyl, or may form a ring with the nitrogen atom to which they are attached,     and certain provisos. Processes for making the compounds and pharmaceutical formulations containing them, eg for the treatment of conditions including excess gastric acidd secretion, are also described.

  描述了一种具有I式化合物的化合物，其中R₁至R₈具有各种含义，包括烷氧基、氢、烷基，n为0或1，R₁₁为氢、苯基、烯基或烷基，可选择地被苯基取代，R₉和R₁₀具有各种含义，包括环烷基、烷基，或者可以与它们连接的氮原子形成环，并附有某些条款。还描述了制备这些化合物和含有它们的制药配方的方法，例如用于治疗包括胃酸过多分泌在内的疾病。