Aminonaphthalylhydrazid | 2890-10-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: Aminonaphthalylhydrazid
• 英文别名: 7-Amino-naphthalin-dicarbonsaeure-(1,2)-hydrazid；9-amino-2,3-dihydro-benzo[f]phthalazine-1,4-dione；9-Amino-2,3-dihydrobenzo[f]phthalazine-1,4-dione
• CAS: 2890-10-0
• 化学式: C₁₂H₉N₃O₂
• 分子量: 227.222
• InChiKey: VXNUSLPOSHEXHY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  17
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  84.2
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• Kit and method for the labelling of biomolecules
  申请人：Cyanagen Srl

  公开号：EP2314597A1

  公开（公告）日：2011-04-27

  The present invention relates to a kit for the labelling of biomolecules bearing reactive amino or hydroxyl groups. The kit consists of a Reagent A and a Reagent B, individually packaged, comprising: a mixture of a carboxylated labelling compound and a tertiary amine (Reagent A); and a coupling reagent (Reagent B). Upon contacting Reagent A with Reagent B, the carboxylated labelling compound is activated in-situ by the coupling reagent (a guanidinium, or uronium salt) in the presence of the tertiary amine. The active form of the carboxylated labelling compound is reacted with a biomolecules bearing reactive amino or hydroxyl groups, with formation of a stable covalent bond between the carboxylated labelling compound and the biomolecule.

  本发明涉及一种对带有活性氨基或羟基的生物大分子进行标记的试剂盒。该试剂盒包括单独包装的试剂 A 和试剂 B，其中试剂 A 是羧基化标记化合物和叔胺的混合物；试剂 B 是偶联试剂。试剂 A 与试剂 B 接触后，羧化标记化合物在叔胺存在下被偶联试剂（胍盐或脲盐）原位活化。羧化标记化合物的活性形式与带有活性氨基或羟基的生物大分子反应，在羧化标记化合物和生物大分子之间形成稳定的共价键。
• KIT AND METHOD FOR THE LABELLING OF BIOMOLECULES
  申请人：DELLA CIANA Leopoldo

  公开号：US20110092676A1

  公开（公告）日：2011-04-21

  The present invention relates to a kit for the labelling of biomolecules bearing reactive amino or hydroxyl groups. The kit consists of a Reagent A and a Reagent B, individually packaged, comprising: a mixture of a carboxylated labelling compound and a tertiary amine (Reagent A); and a coupling reagent (Reagent B). Upon contacting Reagent A with Reagent B, the carboxylated labelling compound is activated in-situ by the coupling reagent (a guanidinium, or uranium salt) in the presence of the tertiary amine. The active form of the carboxylated labelling compound is reacted with a biomolecules bearing reactive amino or hydroxyl groups, with formation of a stable covalent bond between the carboxylated labelling compound and the biomolecule.