7α-Hydroxy-5α-androstan-3-on | 25846-04-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 7α-Hydroxy-5α-androstan-3-on
• 英文别名: (5S,7R,8S,9S,10S,13S,14S)-7-hydroxy-10,13-dimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-one
• CAS: 25846-04-2
• 化学式: C₁₉H₃₀O₂
• 分子量: 290.446
• InChiKey: MLLXWRSMWXSEBS-CORSCNNSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  21
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• KITS FOR DETECTING AND MONITORING ENDOCRINE DISRUPTING CHEMICALS (EDCs)
  申请人：THE UNITED STATES OF AMERICA, as represented by the Secretary, Dept. of Health and Human Services

  公开号：US20150168416A1

  公开（公告）日：2015-06-18

  Described herein are compositions, methods, a system, and kits for detection of endocrine disruptor chemicals (EDCs) in environmental and other samples, such as samples of water including but not limited to waste water treatment plant effluent, using a live-cell fluorescence-based nuclear translocation reporter system. Upon binding of a ligand to a fluorescent-labeled reporter protein, the protein (and therefore the fluorescence) is translocated in a ligand level-dependent manner from the cytoplasm to the nucleus of live mammalian cells; this translocation is detectable as diffuse (cytoplasmic) fluorescence converting to localized, brightly fluorescent nuclei. The described methods, kits and system can be used to reliably detect very low levels of EDC contamination, including in high throughput analysis systems as described.
• METHODS FOR DETECTING AND MONITORING ENDOCRINE DISRUPTING CHEMICALS (EDCs)
  申请人：THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human

  公开号：US20150219628A1

  公开（公告）日：2015-08-06

  Described herein are compositions, methods, a system, and kits for detection of endocrine disruptor chemicals (EDCs) in samples, such as samples of water including but not limited to waste water treatment plant effluent, using a live-cell fluorescence-based nuclear translocation reporter system. Upon binding of a ligand to a fluorescent-labeled reporter protein, the protein (and therefore the fluorescence) is translocated in a ligand level-dependent manner from the cytoplasm to the nucleus of live mammalian cells; this translocation is detectable as diffuse (cytoplasmic) fluorescence converting to localized, brightly fluorescent nuclei. The described kits can be used to reliably detect very low levels of EDC contamination, including in high throughput analysis systems as described.
• US9040248B2
  申请人：——

  公开号：US9040248B2

  公开（公告）日：2015-05-26
• US9921211B2
  申请人：——

  公开号：US9921211B2

  公开（公告）日：2018-03-20