A new combination is described comprising one or more antimicrobial peptides derived from Naja atra cardiotoxins, one or more disinfectants selected from the group of quaternary ammonium compounds and/or organomercuric compounds and, optionally, one or more chelating agents. Antimicrobial peptides belong to the formula KLI-X1-SKTIPA-X2-KNL-X3-YKI, where the variable residues X1, X2 and X3 are further defined in the description. Pharmaceutical compositions and kits based on the above mentioned combination are also described. The combination according to the invention presents an enhanced, synergistic and selective activity towards Gram negative bacteria; the invention includes the use of the above mentioned combination in the treatment or prevention of Gram negative bacterial infections.
描述了一种新的组合物,其中包括一种或多种来源于Naja atra心脏毒素的抗菌肽、一种或多种选自季
铵化合物和/或有机
汞化合物组的消毒剂,以及可选的一种或多种
螯合剂。抗菌肽属于式 KLI-X1-SKTIPA-X2-KNL-X3-YKI,其中可变残基 X1、X2 和 X3 在描述中进一步定义。还描述了基于上述组合的药物组合物和试剂盒。根据本发明的组合物对革兰氏阴性菌具有增强、协同和选择性活性;本发明包括将上述组合物用于治疗或预防革兰氏阴性菌感染。