15α-hydroxybufalin 3-acetate | 4534-19-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 15α-hydroxybufalin 3-acetate
• 英文别名: [(3S,5R,8R,9S,10S,13R,14S,15S,17R)-14,15-dihydroxy-10,13-dimethyl-17-(6-oxopyran-3-yl)-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-yl] acetate
• CAS: 4534-19-4
• 化学式: C₂₆H₃₆O₆
• 分子量: 444.568
• InChiKey: XFPUHZSRQDIMPV-KDXVLYHISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  32
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.77
• 拓扑面积：
  93.1
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• MODULATORS OF HYPOXIA INDUCIBLE FACTOR-1 AND RELATED USES FOR THE TREATMENT OF OCULAR DISORDERS
  申请人：Bionaut Pharmaceuticals

  公开号：EP1928470A2

  公开（公告）日：2008-06-11
• Modulators of Hypoxia Inducible Factor-1 and Related Uses for the Treatment of Ocular Disorders
  申请人：Khodadoust Mehran

  公开号：US20110076278A1

  公开（公告）日：2011-03-31

  Methods for treatment of ocular disorders using steroids modulate the effects of local and systemic hypoxic events mediated by hypoxia inducible factor-1 (HIF-1). Steroids that are useful as HIF-1 modulators include bufalin, digitoxigenin, digoxin, lanatoside C, strophantin K, uzarigenin, ouabain and proscillaridin. In some embodiments the ocular disorder is characterized by ischmia.
• [EN] MODULATORS OF HYPOXIA INDUCIBLE FACTOR-1 AND RELATED USES FOR THE TREATMENT OF OCULAR DISORDERS<br/>[FR] MODULATEURS DU FACTEUR 1 INDUIT PAR HYPOXIE ET UTILISATIONS ASSOCIEES DANS LE TRAITEMENT DE TROUBLES OCULAIRES
  申请人：BIONAUT PHARMACEUTICALS

  公开号：WO2007016656A2

  公开（公告）日：2007-02-08

  (EN) Methods for treatment of ocular disorders using steroids modulate the effects of local and systemic hypoxic events mediated by hypoxia inducible factor- 1 (HIF-1). Steroids that are useful as HIF-1 modulators include bufalin, digitoxigenin, digoxin, lanatoside C, strophantin K, uzarigenin, ouabain and proscillaridin. In some embodiments the ocular disorder is characterized by ischmia.(FR) L'invention concerne des méthodes de traitement de troubles oculaires à l'aide de composés modulant les effets d'évènements hypoxiques locaux et systémiques.