7-Chloro-2-(1H-imidazol-1-yl)-6-iodo-4(3H)-quinazolinone | 540501-12-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 7-Chloro-2-(1H-imidazol-1-yl)-6-iodo-4(3H)-quinazolinone
• 英文别名: 7-chloro-2-imidazol-1-yl-6-iodo-3H-quinazolin-4-one
• CAS: 540501-12-0
• 化学式: C₁₁H₆ClIN₄O
• 分子量: 372.55
• InChiKey: RGYQAGNNDVCVEE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  59.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Inflammation modulators
  申请人：Tularik Inc.

  公开号：US20030181472A1

  公开（公告）日：2003-09-25

  Compounds, compositions and methods that are useful in the treatment of inflammatory, immunoregulatory, metabolic and cell proliferative conditions or diseases are provided herein. In particular, the invention provides compounds which modulate the expression and/or function of proteins involved in inflammation, metabolism and cell proliferation. The subject compounds contain quinoline or quinazoline rings.

  本文提供了在治疗炎症、免疫调节、代谢和细胞增殖疾病中有用的化合物、组合物和方法。特别地，本发明提供了调节参与炎症、代谢和细胞增殖的蛋白质表达和/或功能的化合物。所述化合物含有喹啉或喹嗪环。
• US7176314B2
  申请人：——

  公开号：US7176314B2

  公开（公告）日：2007-02-13
• [EN] INFLAMMATION MODULATORS<br/>[FR] MODULATEURS D'INFLAMMATION
  申请人：TULARIK INC

  公开号：WO2003048152A2

  公开（公告）日：2003-06-12

  Compounds, compositions and methods that are useful in the treatment of inflammatory, immunoregulatory, metabolic and cell proliferative conditions or diseases are provided herein. In particular, the invention provides compounds which modulate the expression and/or function of proteins involved in inflammation, metabolism and cell proliferation. The subject compounds contain quinoline or quinazoline rings.