(+/-)-3-(3-amino-phenyl)-2-methyl-propionic acid | 41201-56-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 苯丙酸
• 英文名称: (+/-)-3-(3-amino-phenyl)-2-methyl-propionic acid
• 英文别名: (+/-)-3-(3-Amino-phenyl)-2-methyl-propionsaeure；β-(3-Amino-phenyl)-isobuttersaeure；3-(3-Aminophenyl)-2-methylpropanoic acid
• CAS: 41201-56-3
• 化学式: C₁₀H₁₃NO₂
• 分子量: 179.219
• InChiKey: PSHHGHLPWFEVLB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  63.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (+/-)-3-(3-amino-phenyl)-2-methyl-propionic acid 生成 3-(3-benzoylamino-phenyl)-2-methyl-propionic acid
  参考文献：
  名称：

  v. Miller; Rohde, Chemische Berichte, 1890, vol. 23, p. 1899

  摘要：

  DOI：
• 作为产物：
  描述：

  2-甲基-3-(3-硝基苯基)丙烯酸 在 乙醇 、 铂 作用下， 生成 (+/-)-3-(3-amino-phenyl)-2-methyl-propionic acid
  参考文献：
  名称：

  Nerdel; John, Chemische Berichte, 1956, vol. 89, p. 1945,1949

  摘要：

  DOI：

文献信息

• TAILOR-MADE MULTIFUNCTIONAL STEM CELLS AND UTILIZATION THEREOF
  申请人：ReproCELL Inc.

  公开号：EP1437404A1

  公开（公告）日：2004-07-14

  An object of the present invention is to efficiently establish cells, tissues, and organs capable of serving as donors for treating diseases, without eliciting immune rejection reactions, without starting with an egg cell. This object was achieved by providing a pluripotent stem cell having a desired genome. The cell was produced by treating with a reprogramming agent, producing a fusion cell of an MHC deficient stem cell with a somatic cell, or after producing a fusion cell of a stem cell with a somatic cell, removing a gene derived from the stem cell by performing genetic manipulation with a retrovirus.

  本发明的目的是在不引起免疫排斥反应的情况下，不从卵细胞开始，有效地建立能够作为治疗疾病供体的细胞、组织和器官。实现这一目标的方法是提供一种具有所需基因组的多能干细胞。该细胞是通过以下方法产生的：用重编程剂处理，产生 MHC 缺陷干细胞与体细胞的融合细胞，或在产生干细胞与体细胞的融合细胞后，用逆转录病毒进行遗传操作，去除干细胞中的基因。
• METHOD OF TARGETED GENE DISRUPTION, GENOME OF HYPERTHERMOSTABLE BACTERIUM AND GENOME CHIP USING THE SAME
  申请人：Japan Science and Technology Agency

  公开号：EP1548105A1

  公开（公告）日：2005-06-29

  It is intended to provide an efficient and sure gene targeting method embodied at an arbitrary position in the genome of an organism and a kit therefor. It is also intended to provide a method for targeted-disruption of an arbitrary gene in the genome of an organism which comprises: 1) the step of providing the whole sequencial data of the genome of the organism; 2) the step of selecting at least one arbitrary region in the sequence; 3) the step of providing a vector containing a sequence homologous with the region selected above and a marker gene; 4) the step of transforming the organism by the vector; and 5) the step of providing the organism under such conditions as allowing homologous recombination. Moreover, the genome of a hyperthermostable bacterium and its array are provided.

  本发明旨在提供一种高效、可靠的基因打靶方法，该方法体现在生物体基因组的任意位置上，并提供一种试剂盒。本发明还旨在提供一种对生物体基因组中任意基因进行靶向破坏的方法，该方法包括1）提供生物体基因组的全部序列数据；2）在序列中选择至少一个任意区域；3）提供含有与上述选择区域同源的序列和标记基因的载体；4）用载体转化生物体；5）在允许同源重组的条件下提供生物体。此外，还提供了一种超恒温细菌的基因组及其阵列。
• Ligase of a hyperthermostable bacterium and chip using the same
  申请人：Japan Science and Technology Agency

  公开号：EP1923464A1

  公开（公告）日：2008-05-21

  It is intended to provide an efficient and sure gene targeting method embodied at an arbitrary position in the genome of an organism and a kit therefor. It is also intended to provide a method for targeted-disruption of an arbitrary gene in the genome of an organism which comprises: 1) the step of providing the whole sequencial data of the genome of the organism; 2) the step of selecting at least one arbitrary region in the sequence; 3) the step of providing a vector containing a sequence homologous with the region selected above and a marker gene; 4) the step of transforming the organism by the vector; and 5) the step of providing the organism under such conditions as allowing homologous recombination. Moreover, the genome of a hyperthermostable bacterium and its array are provided.

  本发明旨在提供一种高效、可靠的基因打靶方法，该方法体现在生物体基因组的任意位置上，并提供一种试剂盒。本发明还旨在提供一种对生物体基因组中任意基因进行靶向破坏的方法，该方法包括1）提供生物体基因组的全部序列数据；2）在序列中选择至少一个任意区域；3）提供含有与上述选择区域同源的序列和标记基因的载体；4）用载体转化生物体；5）在允许同源重组的条件下提供生物体。此外，还提供了一种超恒温细菌的基因组及其阵列。
• Biotinylated and oxidized LDL receptor and advanced glycation end product receptor produced using genetically engineered silkworm
  申请人：National Agriculture and Food Research Organization

  公开号：US11311002B2

  公开（公告）日：2022-04-26

  The present invention pertains to a silkworm-type biotinylated CTLD14 or sRAGE and a method for manufacturing the same. One embodiment of the present invention provides a method for manufacturing biotinylated proteins, wherein the method includes A) a step for inserting a nucleic acid molecule for coding biotin ligase and protein in a coexpressable manner into a silkworm or a living organism that imparts sugar chains that are the same as the sugar chains of the silkworm, B) a step for causing the biotin ligase and protein to be expressed by disposing the silkworm or the living organism that imparts sugar chains that are the same as the sugar chains of the silkworm to conditions with which the nucleic acid molecule will carry out expression, and C) a step for administering biotin to the living organism and obtaining the biotinylated protein.

  本发明涉及一种家蚕型生物素化 CTLD14 或 sRAGE 及其制造方法。本发明的一个实施方案提供了一种制造生物素化蛋白质的方法，其中该方法包括 A) 将编码生物素连接酶和蛋白质的核酸分子以可共同表达的方式插入蚕或生物体的步骤，该步骤赋予的糖链与蚕的糖链相同、B）使生物素连接酶和蛋白质表达的步骤，将蚕或赋予与蚕的糖链相同的糖链的活生物体置于核酸分子将进行表达的条件下，以及C）向活生物体施用生物素并获得生物素化蛋白质的步骤。
• Tailor-made multifunctional stem cells and utilization thereof
  申请人：Nakatsuji Norio

  公开号：US20050084968A1

  公开（公告）日：2005-04-21

  An object of the present invention is to efficiently establish cells, tissues, and organs capable of serving as donors for treating diseases, without eliciting immune rejection reactions, without starting with an egg cell. This object was achieved by providing a pluripotent stem cell having a desired genome. The cell was produced by treating with a reprogramming agent, producing a fusion cell of an MHC deficient stem cell with a somatic cell, or after producing a fusion cell of a stem cell with a somatic cell, removing a gene derived from the stem cell by performing genetic manipulation with a retrovirus.

  本发明的目的是在不引起免疫排斥反应的情况下，不从卵细胞开始，有效地建立能够作为治疗疾病供体的细胞、组织和器官。实现这一目标的方法是提供一种具有所需基因组的多能干细胞。该细胞是通过以下方法产生的：用重编程剂处理，产生 MHC 缺陷干细胞与体细胞的融合细胞，或在产生干细胞与体细胞的融合细胞后，用逆转录病毒进行遗传操作，去除干细胞中的基因。