Naphthalin-2,3-disulfonsaeure | 46887-48-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: Naphthalin-2,3-disulfonsaeure
• 英文别名: Naphthalin-disulfonsaeure-(2,3)；2,3-Naphthalenedisulfonic acid；naphthalene-2,3-disulfonic acid
• CAS: 46887-48-3
• 化学式: C₁₀H₈O₆S₂
• 分子量: 288.302
• InChiKey: YKFJUBNDHOLBNN-UHFFFAOYSA-N

物化性质

• 密度：
  1.704±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  126
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• Crystalline clopidogrel naphthalenesulfonate or hydrate thereof, method for preparing same and pharmaceutical composition containing same
  申请人：Yun Sangmin

  公开号：US20050228012A1

  公开（公告）日：2005-10-13

  A crystalline clopidogrel naphthalenesulfonate or a hydrate thereof, a method for preparing same, and a pharmaceutical composition containing same are provided.

  提供了一种结晶的氯吡格雷萘磺酸盐或其水合物，一种制备方法以及含有该物质的药物组合物。
• [EN] CRYSTALLINE CLOPIDOGREL NAPHTHALENESULFONATE OR HYDRATE THEREOF, METHOD FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITION CONTAINING SAME<br/>[FR] NAPHTHALENESULFONATE CRISTALLIN DE CLOPIDOGREL OU HYDRATE DE CELUI-CI, PROCEDE PERMETTANT DE LE PREPARER ET COMPOSITION PHARMACEUTIQUE LE CONTENANT
  申请人：HANMI PHARM IND CO LTD

  公开号：WO2005097804A1

  公开（公告）日：2005-10-20

  A crystalline clopidogrel naphthalenesulfonate or a hydrate thereof, a method for preparing same, and a pharmaceutical composition containing same are provided.

  提供一种结晶的氯吡格雷萘磺酸盐或其水合物，以及制备该物质的方法和含有该物质的药物组合物。
• POLYMETHINE ETHERS
  申请人：Yamamoto Chemicals, Inc.

  公开号：EP1637520A1

  公开（公告）日：2006-03-22

  The invention provides novel compounds useful as intermediates for the production of polymethine compounds containing a desired counter ion with high purity and in high yields. Thus provided are polymethine ether compounds of the general formula (I) given below and a method of producing polymethine compounds which comprises bringing those compounds into contact with an acid. In the above formula, R represents an alkyl group, an alkoxyalkyl group or an aryl group which may optionally be substituted, R1 and R2 each independently represents a hydrogen atom, halogen atom, nitro group, alkyl group, alkoxyalkyl group, alkoxy group or alkoxyalkoxy group and R1 and R2 may be bound to each other to form a ring; R3 represents an alkyl group, which may optionally be substituted; L is an alkylene group required for the formation of a ring structure; and X represents a hydrogen atom, halogen atom, alkoxy group, aryloxy group, alkylthio group, arylthio group or substituted amino group.

  本发明提供了可用作中间体的新型化合物，用于生产高纯度和高产率的含有所需反离子的多亚甲基化合物。 因此，本发明提供了如下通式 (I) 的多亚甲基醚化合物，以及一种生产多亚甲基醚化合物的方法，该方法包括使这些化合物与酸接触。 在上式中，R 代表烷基、烷氧基烷基或芳基，可任选被取代；R1 和 R2 各自独立地代表氢原子、卤素原子、硝基、烷基、烷氧基烷基、烷氧基烷基或烷氧基烷氧基；R1 和 R2 可相互结合形成一个环；R3 代表烷基，可任选被取代；L 是形成环状结构所需的亚烷基；X 代表氢原子、卤素原子、烷氧基、芳氧基、烷硫基、芳硫基或取代的氨基。
• Crystalline clopidogrel naphthalenesulfonate hydrate, method for preparing same and pharmaceutical composition containing same
  申请人：Hanmi Holdings Co., Ltd.

  公开号：EP2386560A1

  公开（公告）日：2011-11-16

  A monohydrate of a crystalline clopidogrel naphthalenesulfonate of formula (Ib) whose powder X-ray diffraction scan shows major peaks having I/I0 values greater than 10% at 2θ = 7.6, 9.7, 10.7, 11.0, 12.1, 13.6, 14.2, 15.3, 16.6, 17.0, 18.1, 18.5, 19.8, 21.5, 22.2, 23.0, 23.5, 24.3, 24.8, 25.7, 26.4, 26.9, 27.3, 28.4, 29.0:

  式(Ib)的结晶氯吡格雷萘磺酸盐的一水合物，其粉末 X 射线衍射扫描显示主要峰的 I/I0 值大于 10%，在 2θ = 7.6, 9.7, 10.7, 11.0, 12.1, 13.6, 14.2, 15.3, 16.6, 17.0, 18.1, 18.5, 19.8, 21.5, 22.2, 23.0, 23.5, 24.3, 24.8, 25.7, 26.4, 26.9, 27.3, 28.4, 29.0:
• Polymethine ethers
  申请人：Sasaki Nobuaki

  公开号：US20060167272A1

  公开（公告）日：2006-07-27

  The invention provides novel compounds useful as intermediates for the production of polymethine compounds containing a desired counter ion with high purity and in high yields. Thus provided are polymethine ether compounds of the general formula (I) given below and a method of producing polymethine compounds which comprises bringing those compounds into contact with an acid. In the above formula, R represents an alkyl group, an alkoxyalkyl group or an aryl group which may optionally be substituted, R 1 and R 2 each independently represents a hydrogen atom, halogen atom, nitro group, alkyl group, alkoxyalkyl group, alkoxy group or alkoxyalkoxy group and R 1 and R 2 may be bound to each other to form a ring; R 3 represents an alkyl group, which may optionally be substituted; L is an alkylene group required for the formation of a ring structure; and X represents a hydrogen atom, halogen atom, alkoxy group, aryloxy group, alkylthio group, arylthio group or substituted amino group.

  本发明提供了可用作中间体的新型化合物，用于生产高纯度和高产率的含有所需反离子的多亚甲基化合物。 因此，本发明提供了下式（I）通式的多亚甲基醚化合物和一种生产多亚甲基醚化合物的方法，该方法包括使这些化合物与酸接触。 在上式中，R 代表烷基、烷氧基烷基或芳基，可任选被取代，R 1 和 R 2 各自独立地代表氢原子、卤素原子、硝基、烷基、烷氧基烷基、烷氧基或烷氧基烷氧基，R 1 和 R 2 可相互结合形成一个环；R 3 代表烷基，可选择被取代；L 是形成环状结构所需的亚烷基；X 代表氢原子、卤素原子、烷氧基、芳氧基、烷硫基、芳硫基或取代的氨基。