EVP6124 hydrochloride

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻吩类
• 英文名称: EVP6124 hydrochloride
• 英文别名: N-(1-azabicyclo[2.2.2]octan-3-yl)-7-chloro-1-benzothiophene-2-carboxamide;hydrochloride
• 化学式: C16H18Cl2N2OS
• 分子量: 357.3
• InChiKey: OIJYTJGIDVTCFF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  60.6
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• ANTIPRURITIC AGENT
  申请人：Hayashi Kenichi

  公开号：US20140128606A1

  公开（公告）日：2014-05-08

  An antipruritic which exerts an antipruritic effect based on a novel action mechanism and is effective for pruritus. The antipruritic contains as an effective ingredient a compound which activates a central type nicotinic acetylcholine receptor.

  一种抗瘙痒药物，基于新颖的作用机制发挥抗瘙痒作用，并对瘙痒有效。该抗瘙痒药物含有一种有效成分，该成分可以激活中枢型尼古丁乙酰胆碱受体。
• Crystalline Form of (R)-7-Chloro-N-(Quinuclidin-3-yl)benzo[B]thiophene-2-Carboxamide Hydrochloride Monohydrate
  申请人：Oliver-Shaffer Patricia

  公开号：US20130183380A1

  公开（公告）日：2013-07-18

  Crystalline Forms I and II of (R)-7-chloro-N-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide hydrochloride monohydrate and compositions, methods of manufacture and therapeutic uses thereof are described.

  本文描述了(R)-7-氯-N-(喹硫啶-3-基)苯并[b]噻吩-2-羧酰胺盐酸盐一水合物的晶体形态I和II，以及其组合物、制备方法和治疗用途。
• Crystalline Form of (R)-7-Chloro-N-(Quinuclidin-3-YL)benzo[B]thiophene-2-Carboxamide Hydrochloride Monohydrate
  申请人：ENVIVO PHARMACEUTICALS, INC.

  公开号：US20140249179A1

  公开（公告）日：2014-09-04

  Crystalline Forms I and II of (R)-7-chloro-N-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide hydrochloride monohydrate and compositions, methods of manufacture and therapeutic uses thereof are described.

  描述了(R)-7-氯-N-(喹诺啉-3-基)苯并[b]噻吩-2-羧酰胺盐酸盐一水合物的结晶形式I和II，以及它们的组合物、制造方法和治疗用途。
• CRYSTALLINE FORM OF (R)-7-CHLORO-N-(QUINUCLIDIN-3-YL)BENZO[B]THIOPHENE-2-CARBOXAMIDE HYDROCHLORIDE MONOHYDRATE
  申请人：Forum Pharmaceuticals, Inc.

  公开号：US20160009707A1

  公开（公告）日：2016-01-14

  Crystalline Forms I and II of (R)-7-chloro-N-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide hydrochloride monohydrate and compositions, methods of manufacture and therapeutic uses thereof are described.

  本文描述了(R)-7-氯-N-(喹硫啶-3-基)苯并[b]噻吩-2-羧酰胺盐酸盐一水合物的结晶形式I和II，以及其组合物、制备方法和治疗用途。
• Treatment of negative symptoms of schizophrenia with (R)-7-chloro-N-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide and pharmaceutically acceptable salts thereof
  申请人：Forum Pharmaceuticals Inc.

  公开号：EP2889033A1

  公开（公告）日：2015-07-01

  (R)-7-chloro-N-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide has been found to have precognitive effects in humans at unexpectedly low doses. Thus, (R) -7-chloro-N-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide and pharmaceutically acceptable salts thereof can be used at unexpectedly low doses improve cognition.

  研究发现，(R)-7-氯-N-(quinuclidin-3-yl)苯并[b]噻吩-2-甲酰胺在意外的低剂量下就能对人体产生预知效应。因此，(R)-7-氯-N-(quinuclidin-3-yl)苯并[b]噻吩-2-甲酰胺及其药学上可接受的盐类可以意外的低剂量改善认知能力。