4-N-methyl-4-N-[(3R)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrrolidin-3-yl]pyrimidine-2,4-diamine | 1360093-28-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯并嘧啶类
• 英文名称: 4-N-methyl-4-N-[(3R)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrrolidin-3-yl]pyrimidine-2,4-diamine
• CAS: 1360093-28-2
• 化学式: C₁₅H₁₈N₈
• 分子量: 310.362
• InChiKey: AYGPWQMSAOCGHM-SNVBAGLBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  99.8
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• [EN] PYRROLOPYRIMIDINE COMPOUNDS AND USES THEREOF<br/>[FR] COMPOSÉS DE PYRROLOPYRIMIDINE ET LEURS UTILISATIONS
  申请人：HUTCHISON MEDIPHARMA LTD

  公开号：WO2012022265A1

  公开（公告）日：2012-02-23

  Disclosed are pyrrolopyrimidine compounds of formula (I) capable of inhibiting JAK kinase, wherein R1, R2 and m are defined as in the description. The pharmaceutical compositions containing said pyrrolopyrimidine compounds and uses of said pyrrolopyrimidine compounds in the treatment of disorders or diseases such as inflammatory diseases and cancers are also disclosed.

  公开了具有以下式（I）的吡咯吡嘧啶化合物，能够抑制JAK激酶，其中R1、R2和m的定义如描述中所述。还公开了含有所述吡咯吡嘧啶化合物的药物组合物，以及所述吡咯吡嘧啶化合物在治疗炎症性疾病和癌症等疾病或疾病中的用途。
• PYRROLOPYRIMIDINE COMPOUNDS AND USES THEREOF
  申请人：Su Wei-Guo

  公开号：US20130210831A1

  公开（公告）日：2013-08-15

  The present disclosure provides pyrrolopyrimidine compounds and methods of use therefor. For example, the disclosure provides certain pyrrolopyrimidine compounds capable of inhibiting JAK kinases. The disclosure further provides the pharmaceutical compositions containing these pyrrolopyrimidine compounds, and use of these pyrrolopyrimidine compounds in the treatment of disorders or diseases, such as inflammatory diseases and cancer.

  本公开提供吡咯吡嘧啶化合物及其使用方法。例如，本公开提供某些能够抑制JAK激酶的吡咯吡嘧啶化合物。本公开还提供含有这些吡咯吡嘧啶化合物的药物组合物，以及利用这些吡咯吡嘧啶化合物治疗炎症性疾病和癌症等疾病的方法。
• [EN] PYRROLOPYRIMIDINE COMPOUNDS AND USES THEREOF<br/>[FR] COMPOSÉS PYRROLOPYRIMIDINIQUES ET LEURS UTILISATIONS
  申请人：HUTCHISON MEDIPHARMA LTD

  公开号：WO2012022045A1

  公开（公告）日：2012-02-23

  The present invention provides pyrrolopyrimidine compounds and methods of use therefor. In particular, the invention provides certain pyrrolopyrimidine compounds having the activity of inhibiting JAK kinases. The invention also provides the pharmaceutical compositions containing these pyrrolopyrimidine compounds and use of these compounds in the treatment of inflammatory diseases and cancer.

  本发明提供吡咯吡嘧啶化合物及其使用方法。具体而言，本发明提供具有抑制JAK激酶活性的特定吡咯吡嘧啶化合物。本发明还提供含有这些吡咯吡嘧啶化合物的药物组合物，并将这些化合物用于治疗炎症性疾病和癌症。
• Pyrrolopyrimidine compounds and uses thereof
  申请人：HUTCHISON MEDIPHARMA LIMITED

  公开号：US10369153B2

  公开（公告）日：2019-08-06

  The present disclosure provides pyrrolopyrimidine compounds and methods of use therefor. For example, the disclosure provides certain pyrrolopyrimidine compounds capable of inhibiting JAK kinases. The disclosure further provides the pharmaceutical compositions containing these pyrrolopyrimidine compounds, and use of these pyrrolopyrimidine compounds in the treatment of disorders or diseases, such as inflammatory diseases and cancer.

  本公开提供了吡咯并嘧啶化合物及其使用方法。例如，本公开提供了某些能够抑制 JAK 激酶的吡咯并嘧啶化合物。本公开进一步提供了含有这些吡咯并嘧啶化合物的药物组合物，以及这些吡咯并嘧啶化合物在治疗紊乱或疾病（如炎症性疾病和癌症）中的用途。
• US9346810B2
  申请人：——

  公开号：US9346810B2

  公开（公告）日：2016-05-24