N-cyclopropyl-4-methyl-3-[2-oxo-3-[[(1R)-1,2,3,4-tetrahydro-1-naphthalenyl]amino]-1(2H)-pyrazinyl]-benzamide | 1095002-26-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: N-cyclopropyl-4-methyl-3-[2-oxo-3-[[(1R)-1,2,3,4-tetrahydro-1-naphthalenyl]amino]-1(2H)-pyrazinyl]-benzamide
• 英文别名: N-cyclopropyl-4-methyl-3-[2-oxo-3-[[(1R)-1,2,3,4-tetrahydronaphthalen-1-yl]amino]pyrazin-1-yl]benzamide
• CAS: 1095002-26-8
• 化学式: C₂₅H₂₆N₄O₂
• 分子量: 414.507
• InChiKey: KKEDMLWTOJTAAN-OAQYLSRUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  31
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  73.8
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Nicotinamide benzofused-heterocyclyl derivatives useful as selective inhibitors of pde4 isozymes
  申请人：——

  公开号：US20030186989A1

  公开（公告）日：2003-10-02

  Compounds useful as inhibitors of PDE4 in the treatment of diseases regulated by the activation and degranulation of eosinophils, especially asthma, chronic bronchitis, and chronic obstructive pulmonary disease, of Formula (1.0.0): 1 wherein R 5 and R 6 are taken together to form a moiety of partial Formulas (1.1.1) through (1.1.5): 2 or a pharmaceutically acceptable salt thereof.

  在治疗由嗜酸性粒细胞的激活和脱颗粒调节的疾病，特别是哮喘、慢性支气管炎和慢性阻塞性肺病中作为PDE4抑制剂有用的化合物，其化学式为（1.0.0）： 其中R5和R6一起取代形成部分化学式（1.1.1）至（1.1.5）的基团， 或其药用可接受的盐。
• Pyrimidine carboxamides useful as inhibitors of pde4 isozymes
  申请人：——

  公开号：US20030144300A1

  公开（公告）日：2003-07-31

  Compounds of formula (1.0.0) are described, as well as the usefulness of a pharmaceutical composition for treating inflammatory, respiratory and allergic diseases and conditions, especially asthma; chronic obstructive pulmonary disease (COPD) including chronic bronchitis, emphysema, and bronchiectasis; chronic rhinitis; and chronic sinusitis.

  描述了化学式（1.0.0）的化合物，以及用于治疗炎症性、呼吸道和过敏性疾病和症状的药物组合物的用途，特别是哮喘；慢性阻塞性肺病（COPD），包括慢性支气管炎、肺气肿和支气管扩张症；慢性鼻炎；和慢性鼻窦炎。
• [EN] CARBONIC ANHYDRASE INHIBITORS<br/>[FR] INHIBITEURS D'ANHYDRASE CARBONIQUE
  申请人：UNIV GRIFFITH

  公开号：WO2018204987A1

  公开（公告）日：2018-11-15

  Compounds are provided which are inhibitors of the CAXII enzyme. Due to the interaction between CAXII and Pgp, such compounds may be useful in lowering the chemoresistance of a cancer allowing for co-administration with existing anti-cancer agents.

  提供了抑制CAXII酶的化合物。由于CAXII和Pgp之间的相互作用，这些化合物可能有助于降低癌症的化疗抗药性，从而可以与现有的抗癌药物同时使用。
• USE OF TARGETED NITROXIDE AGENTS IN BONE HEALING
  申请人：Epperly Michael W.

  公开号：US20120252733A1

  公开（公告）日：2012-10-04

  Provided herein are compositions and related methods useful for accelerating bone healing and growth. The compounds comprise a nitroxide-containing group attached to a mitochondria-targeting group. The compounds can be cross-linked into dimers without loss of activity.

  本文提供了一种促进骨愈合和生长的组合物及相关方法。这些化合物包含一个连接到线粒体靶向基团的亚硝基含有基团。这些化合物可以交联成二聚体而不失去活性。
• COMPOUNDS AND THEIR USES 708
  申请人：BROUGH Stephen

  公开号：US20120065214A1

  公开（公告）日：2012-03-15

  The present invention relates to pyrazinone derivatives of formula (I): wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and R 7 are as herein defined; processes for their preparation, pharmaceutical compositions containing them and their use in therapy.

  本发明涉及公式（I）的吡唑酮衍生物：其中R1、R2、R3、R4、R5、R6和R7如本文所定义；其制备过程，含有它们的制药组合物以及它们在治疗中的应用。