| 63804-15-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚和异茚
• CAS: 63804-15-9
• 化学式: C20H17FNaO3S
• 分子量: 379.4
• InChiKey: YWNNRQKUANBLPZ-WPTDRQDKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.98
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  73.6
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) AND USES THEREOF
  申请人：Zhi Lin

  公开号：US20100256129A1

  公开（公告）日：2010-10-07

  Provided herein are compounds of formulae I to II that bind to androgen receptors and/or modulate activity of androgen receptors; and to methods for making and using such compounds. Also provided are compositions including such compounds and methods for making and using such compositions.

  本文提供了公式I到II的化合物，这些化合物能够结合到雄激素受体并/或调节雄激素受体的活性；以及制备和使用这些化合物的方法。还提供了包括这些化合物的组合物以及制备和使用这些组合物的方法。
• Selective androgen receptor modulators (SARMs) and uses thereof
  申请人：Ligand Pharmaceuticals Incorporated

  公开号：US20130184206A1

  公开（公告）日：2013-07-18

  Provided herein are compounds that bind to androgen receptors and/or modulate activity of androgen receptors. Also provided are methods for making and using such compounds. Also provided are compositions including such compounds and methods for making and using such compositions.

  本文提供了与雄激素受体结合和/或调节雄激素受体活性的化合物。还提供了制备和使用这些化合物的方法。此外，还提供了包括这些化合物的组合物以及制备和使用这些组合物的方法。
• Rapid acting combination of sodium sulindac and a base
  申请人：Merck & Co., Inc.

  公开号：EP0259990A1

  公开（公告）日：1988-03-16

  A combination of sulindac or sodium sulindac and an appropriate base in excess and of a sufficient amount to neutralize gastric acidity for example, tromethamine or sodium bicarbonate, have been found to exhibit unexpectedly rapid absorption and improved onset of activity relative to sulindac and conventional water-soluble formulations containing sodium sulindac.

  研究发现，相对于舒林酸和含有舒林酸钠的传统水溶性制剂，舒林酸或舒林酸钠与过量且足以中和胃酸的适当碱（如氨基丁三醇或碳酸氢钠）的组合具有出乎意料的快速吸收性和更好的起效性。
• Selective androgen receptor modulators (sarms) and uses thereof
  申请人：Ligand Pharmaceuticals Inc.

  公开号：EP2489656A1

  公开（公告）日：2012-08-22

  Provided herein are compounds of formulae I to II that bind to androgen receptors and/or modulate activity of androgen receptors; and to methods for making and using such compounds. Also provided are compositions including such compounds and methods for making and using such compositions.

  本文提供了与雄激素受体结合和/或调节雄激素受体活性的式 I 至式 II 化合物；以及制造和使用此类化合物的方法。还提供了包括此类化合物的组合物以及制造和使用此类组合物的方法。
• Methods and compositions for modulating hormone levels
  申请人：Ligand Pharmaceuticals Incorporated

  公开号：US10441567B2

  公开（公告）日：2019-10-15

  Provided herein are compositions and methods for the treatment of androgen and estrogen receptors mediated conditions. Specifically, a composition that includes an effective amount of a selective estrogen receptor modulator (SERM) and an effective amount of a 5a-reductase inhibitor, or a pharmaceutically acceptable salt, ester or prodrug of the foregoing is provided. Also provided are methods for the treatment of aging related conditions and diseases.

  本文提供了用于治疗雄激素和雌激素受体介导的疾病的组合物和方法。具体来说，提供了一种组合物，其中包括有效量的选择性雌激素受体调节剂（SERM）和有效量的 5a 还原酶抑制剂，或上述物质的药学上可接受的盐、酯或原药。还提供了治疗与衰老有关的病症和疾病的方法。