N-[(4R)-6-fluoro-3,3',4,4'-tetrahydro-2'H-spiro[chromene-2,1'-cyclobutan]-4-yl]-N'-[(7R)-7-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl]urea | 1144501-13-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: N-[(4R)-6-fluoro-3,3',4,4'-tetrahydro-2'H-spiro[chromene-2,1'-cyclobutan]-4-yl]-N'-[(7R)-7-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl]urea
• 英文别名: 1-[(4R)-6-fluorospiro[3,4-dihydrochromene-2,1'-cyclobutane]-4-yl]-3-[(7R)-7-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl]urea
• CAS: 1144501-13-2
• 化学式: C₂₃H₂₅FN₂O₃
• 分子量: 396.462
• InChiKey: SJHWGECHEIPFBA-OXQOHEQNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  29
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  70.6
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• TRPV1 ANTAGONISTS
  申请人：Gomtsyan Arthur R.

  公开号：US20100120846A1

  公开（公告）日：2010-05-13

  Disclosed herein are compounds of formula (I), or pharmaceutically acceptable salts, solvates, prodrugs, salts of prodrugs, or combinations thereof, wherein R 1 , R 2 , R 3 , R 4 , and m are defined in the specification. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also disclosed.

  本文揭示了式(I)的化合物，或其药学上可接受的盐、溶剂、前药盐、前药的盐或其组合物，其中R1、R2、R3、R4和m在规范中被定义。还揭示了包含这些化合物的组合物以及使用这些化合物和组合物治疗疾病和病症的方法。
• SOLID DISPERSION PRODUCT CONTAINING N-ARYL UREA-BASED COMPOUND
  申请人：Schroeder Rudolf

  公开号：US20090143423A1

  公开（公告）日：2009-06-04

  A solid dispersion product comprising at least one N-aryl urea-based pharmaceutically active agent or an agent of related structural type is obtained by a) preparing a liquid mixture containing the at least one active agent, at least one pharmaceutically acceptable matrix-forming agent, at least one pharmaceutically acceptable surfactant and at least one solvent, and b) removing the solvent(s) from the liquid mixture to obtain the solid dispersion product.

  通过a)制备含有至少一种N-芳基脲基药物活性剂或相关结构类型的药剂学活性剂的固体分散产品，包括制备液体混合物，其中包含至少一种活性剂、至少一种药学上可接受的基质形成剂、至少一种药学上可接受的表面活性剂和至少一种溶剂，然后b)从液体混合物中去除溶剂，以获得固体分散物。
• US8604053B2
  申请人：——

  公开号：US8604053B2

  公开（公告）日：2013-12-10
• US8609692B2
  申请人：——

  公开号：US8609692B2

  公开（公告）日：2013-12-17
• [EN] SOLID DISPERSION PRODUCT CONTAINING N-ARYL UREA-BASED COMPOUND<br/>[FR] PRODUIT DE DISPERSION SOLIDE CONTENANT UN COMPOSÉ N-ARYLE À BASE D'URÉE
  申请人：ABBOTT GMBH & CO KG

  公开号：WO2009050289A2

  公开（公告）日：2009-04-23

  A solid dispersion product comprising at least one N-aryl urea-based pharmaceutically active agent or an agent of related structural type is obtained by a) preparing a liquid mixture containing the at least one active agent, at least one pharmaceutically acceptable matrix-forming agent, at least one pharmaceutically acceptable surfactant and at least one solvent, and b) removing the solvent(s) from the liquid mixture to obtain the solid dispersion product.