ethyl 6-fluoro-7-[(4-fluorophenyl)]-2-trifluoromethyl-[1,8]-naphthyridme-3-carboxylate | 1188434-12-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: ethyl 6-fluoro-7-[(4-fluorophenyl)]-2-trifluoromethyl-[1,8]-naphthyridme-3-carboxylate
• 英文别名: 2-(Trifluoromethyl)-6-fluoro-7-(4-fluorophenyl)-1,8-naphthyridine-3-carboxylic acid ethyl ester；ethyl 6-fluoro-7-(4-fluorophenyl)-2-(trifluoromethyl)-1,8-naphthyridine-3-carboxylate
• CAS: 1188434-12-9
• 化学式: C₁₈H₁₁F₅N₂O₂
• 分子量: 382.29
• InChiKey: AIZRSJUHJNHLCE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  52.1
• 氢给体数：
  0
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  ethyl 8-oxy-6-fluoro-2-trifluoromethyl-[1,8]-naphthyridine-3-carboxylate 、 4-氟苯硼酸 以 甲苯 为溶剂， 反应 16.0h， 以50%的产率得到ethyl 6-fluoro-7-[(4-fluorophenyl)]-2-trifluoromethyl-[1,8]-naphthyridme-3-carboxylate
  参考文献：
  名称：

  Synthesis of 7-aryl-1,8-naphthyridines via addition of aryl boronic acids to 1,8-naphthyridine N-oxides

  摘要：

  Simply combining aryl boronic acids with 1,8-naphthyridine N-oxides and heating at 110 degrees C in toluene or dimethylformamide affords the corresponding 7-aryl-1,8-naphthyridines. The reaction is not sensitive to air or moisture and the process can be extended to other electron-deficient heteroaromatic N-oxides. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.07.040

文献信息

• HERBICIDAL COMPOUNDS
  申请人：Mitchell Glynn

  公开号：US20110021352A1

  公开（公告）日：2011-01-27

  The present invention relates to novel herbicidal [1,8]-naphthyridines of Formula (Ia) or (Ib), or an agronomically acceptable salt of said compound wherein R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , n, m, X and Q are as defined herein. The invention further relates to processes and intermediates for the preparation of the [1,8]-naphthyridines, to compositions which comprise the herbicidal compounds, and to their use for controlling weeds, in particular in crops of useful plants.

  本发明涉及新型除草剂[1,8]-萘啶类化合物，其化学式为(Ia)或(Ib)，或其农业上可接受的盐，其中R2、R3、R4、R5、R6、R7、R8、n、m、X和Q如本文所定义。本发明还涉及制备[1,8]-萘啶类化合物的工艺和中间体，包括含有除草剂化合物的组合物，以及它们在控制杂草方面的用途，特别是在有用植物的作物中。
• HERBICIDAL COUMPOUNDS
  申请人：Syngenta Limited

  公开号：EP2265120B1

  公开（公告）日：2012-03-07
• US8461083B2
  申请人：——

  公开号：US8461083B2

  公开（公告）日：2013-06-11
• Synthesis of 7-aryl-1,8-naphthyridines via addition of aryl boronic acids to 1,8-naphthyridine N-oxides
  作者：Linsey S. Bennie、Paul M. Burton、James A. Morris

  DOI：10.1016/j.tetlet.2011.07.040

  日期：2011.9

  Simply combining aryl boronic acids with 1,8-naphthyridine N-oxides and heating at 110 degrees C in toluene or dimethylformamide affords the corresponding 7-aryl-1,8-naphthyridines. The reaction is not sensitive to air or moisture and the process can be extended to other electron-deficient heteroaromatic N-oxides. (C) 2011 Elsevier Ltd. All rights reserved.