3-羟丙基三甲基碘化铵 | 5930-60-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 3-羟丙基三甲基碘化铵
• 英文名称: <3-Hydroxy-propyl>-trimethylammonium-jodid
• 英文别名: N,N,N-trimethyl-N-(3-hydroxypropyl)ammonium iodide；3-hydroxypropyl(trimethyl)azanium;iodide
• CAS: 5930-60-9
• 化学式: C₆H₁₆NO*I
• 分子量: 245.104
• InChiKey: VTIABHYGTVNNNI-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -2.92
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-羟丙基三甲基碘化铵 在 盐酸 作用下， 生成 N,N′,N″-trimethyl-3-hydroxypropylammonium chloride
  参考文献：
  名称：

  Viologens with charged groups: New redox carriers in reactions of photocatalytic separation of hydrogen from water in homogeneous and vesicular systems

  摘要：

  DOI：

  10.1007/bf00957296
• 作为产物：
  描述：

  3-二甲氨基-1-丙醇 、 碘甲烷 以 乙腈 为溶剂， 反应 2.0h， 以10.4 g的产率得到3-羟丙基三甲基碘化铵
  参考文献：
  名称：

  一种青蒿素的衍生物及其制备方法与应用

  摘要：

  本发明公开了一种青蒿素衍生物及其制备方法与应用。所述青蒿素衍生物的结构式如式I所示。该化合物具有适宜的溶解度，储存条件下相对稳定，经过药代实验表明在眼组织中能够检测到青蒿素，并且角膜、结膜、房水中均有分布，达到较高的药物浓度，为优良的青蒿素前体药物，本发明式I化合物具有显著的可吸收性，在眼组织中的药物浓度显示吸收良好，在烧伤模型的新生血管抑制作用显著优于青蒿素，能够制备成液体制剂，如滴眼液和注射液等，用于治疗眼组织疾病。

  公开号：

  CN114933603A

文献信息

• METHOD FOR PREPARING SITE-SPECIFICALLY MODIFIED PROTEIN BASED ON NOVEL CARBON-CARBON BOND FORMATION
  申请人：Korea Advanced Institute of Science and Technology

  公开号：US20180066011A1

  公开（公告）日：2018-03-08

  A method for producing a site-specifically modified protein based on new carbon-carbon bond formation is disclosed, including the following three steps (marking, activation, and coupling steps): (a) marking of the modification site by incorporating a specific amino acid into a selected position of a target protein; (b) activation of the marked site; and (c) coupling of various post-translational modification (PTM) moieties or other chemical groups onto the activated site to obtain a site-specifically modified protein. The method for producing a site-specifically modified protein can incorporate desired diverse chemical groups including post-translational modification (PTM) moieties into a designated site in a target protein through a new carbon-carbon bond. Furthermore, the modified protein having a site-specific PTM exhibits the same chemical and functional properties as that of a target protein present in cells. Thus, the present invention is useful for studies of cellular proteins, human diseases including cancers and neurodegenerative diseases, and new drug discovery.

  揭示了一种基于新的碳-碳键形成的方法，用于产生具有特定位点修饰的蛋白质，包括以下三个步骤（标记、激活和偶联步骤）：(a) 通过将特定氨基酸纳入目标蛋白质的选定位置来标记修饰位点；(b) 激活标记的位点；以及(c) 将各种翻译后修饰（PTM）基团或其他化学基团偶联到激活位点，从而获得具有特定位点修饰的蛋白质。用于产生具有特定位点修饰的蛋白质的方法可以通过新的碳-碳键将所需的多样化化学基团，包括翻译后修饰（PTM）基团，纳入目标蛋白质的指定位点。此外，具有特定位点PTM的修饰蛋白质表现出与细胞中存在的目标蛋白质相同的化学和功能特性。因此，本发明对于细胞蛋白质、包括癌症和神经退行性疾病在内的人类疾病的研究以及新药物发现是有用的。
• v. Braun; Anton; Weissbach, Chemische Berichte, 1930, vol. 63, p. 2847,2861
  作者：v. Braun、Anton、Weissbach

  DOI：——

  日期：——
• Sterk; Van der Goot; Timmerman, European Journal of Medicinal Chemistry, 1984, vol. 19, # 6, p. 545 - 550
  作者：Sterk、Van der Goot、Timmerman

  DOI：——

  日期：——
• v. Braun, Chemische Berichte, 1916, vol. 49, p. 970
  作者：v. Braun

  DOI：——

  日期：——
• Process for Detecting Gaseous Halogenated Compounds
  申请人：Tran-Thi Thu-Hoa

  公开号：US20100136704A1

  公开（公告）日：2010-06-03

  Process for detecting a gaseous compound of BX 3 , HX or X 2 type within a gas using a composition containing a probe molecule, characterized in that the probe molecule is a molecule for which the reaction with one or more compounds of BX 3 , HX or X 2 type leads to a variation of at least one of its physicochemical properties, this variation being measurable via a suitable analysis technique, and in that the following steps are carried out in this order: (a) measurement of said physicochemical property of the probe molecule, such as a spectral property, (b) bringing the gas into contact with the composition containing the probe molecule from step (a), (c) repeat measurement of said physicochemical property, (d) correlation of the variation of said spectral property between steps (a) and (c) in the presence of said gaseous compound of BX 3 , HX or X 2 type, the measurement of the physicochemical property from step (a) possibly being a prior step, process for trapping gaseous compounds of BX 3 , HX or X 2 type contained in a gas, material capable of reacting with at least one compound of BX 3 , HX or X 2 type in gaseous form and sensor for compounds of BX 3 , HX or X 2 type.