2-deoxy-2-fluorosalacinol | 1023292-11-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机硫酸及其衍生物
• 英文名称: 2-deoxy-2-fluorosalacinol
• 英文别名: 1,2,4-trideoxy-2-fluoro-1,4-[[(2S,3S)-2,4-dihydroxy-3-(sulfooxy)butyl]episulfoniumylidene]-D-arabinitol inner salt
• CAS: 1023292-11-6
• 化学式: C₉H₁₇FO₈S₂
• 分子量: 336.36
• InChiKey: AMBZKRKYKYXXIV-PUNFOFBGSA-N

反应信息

• 作为产物：
  描述：

  1,2,4-trideoxy-2-fluoro-3,5-di-O-p-methoxybenzyl-1,4-[[(2S,3S)-2,4-O-benzylidene-3-(sulfooxy)butyl]episulfoniumylidene]-D-arabinitol inner salt 在 三氟乙酸 作用下， 反应 1.0h， 以75%的产率得到2-deoxy-2-fluorosalacinol
  参考文献：
  名称：

  Synthesis of 2-deoxy-2-fluoro and 1,2-ene derivatives of the naturally occurring glycosidase inhibitor, salacinol, and their inhibitory activities against recombinant human maltase glucoamylase

  摘要：

  2-Deoxy-2-fluorosalacinol and a 1,2-ene derivative of the naturally occurring glycosidase inhibitor salacinol were synthesized for structure activity studies with human maltase glucoamylase (MGA). 2-Deoxy-2-fluorosalacinol was synthesized through the coupling reaction of 2-deoxy-2-fluoro-3,5-di-O-p-methoxybenzyl-1,4-anhydro-4-thio-D-arabinitol with 2,4-O-benzylidene-L-crythritol-1,3-cyclic sulfate in hexafluoroisopropanol (HFIP) containing 0.3 equiv of K2CO3. Excess of K2CO3 resulted in the elimination of HF from the coupled product, and the formation of an alkene derivative of salacinol. Nucleophilic attack of the 1,4-anhydro-4-thio-D-arabinitol moiety on the cyclic sulfate did not proceed in the absence of K2CO3. No reaction was observed in acetonitrile containing K2CO3. The target compounds were obtained by deprotection with TFA. The 2-deoxy-1-ene derivative of salacinol and 2-deoxy-2-fluorosalacinol inhibited recombinant human maltase glucoamylase, one of the key intestinal enzymes involved in the breakdown of glucose, with an IC50 value of 150 mu M and a K-i value of 6 +/- 1 mu M, respectively. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.carres.2008.01.025